Vitenbek I A, Zolotareva A I, Kovalenko G A, Podol'skaia Ia V, Zaripov N A
Vestn Khir Im I I Grek. 1986 Feb;136(2):114-9.
The influence of age, concomitant atherosclerosis and pregnancy on the efficiency of postoperative peridural analgesia with morphine was studied in 2000 patients. It was found that the incidence of adequate analgesia was linearly increased with the age of the patients and the morphine dose. The influence of atherosclerosis and pregnancy manifested itself in the improvement of the analgetic and sedative effect of morphine. The data obtained are thought to be associated with changed permeability of diffuse barriers for the analgetics.
在2000例患者中研究了年龄、合并动脉粥样硬化及妊娠对术后吗啡硬膜外镇痛效果的影响。发现充分镇痛的发生率随患者年龄和吗啡剂量呈线性增加。动脉粥样硬化和妊娠的影响表现为吗啡镇痛和镇静效果的改善。所获得的数据被认为与镇痛药弥散屏障通透性的改变有关。