Centre for Cancer Biology, an Alliance of SA Pathology and University of South Australia, Adelaide, SA 5000, Australia
Department of Medicine, University of Adelaide, Adelaide, SA 5005, Australia
RNA. 2023 Jul;29(7):885-888. doi: 10.1261/rna.079644.123. Epub 2023 Apr 13.
As we continue to find new regulatory roles for RNAs, a theme is emerging in which regulation may not be mediated through the actions of a specific RNA, as one typically thinks of a regulator and target, but rather through the collective nature of many RNAs, each contributing a small degree of the regulatory load. This mechanism has been termed "crowd-control" and may apply broadly to miRNAs and to RNAs that bind and regulate protein activity. This provides an alternative way of thinking about how RNAs can act as biological regulators and has repercussions, both for the understanding of biological systems, and for the interpretation of results in which individual members of the "crowd" can replicate the effects of the crowd when overexpressed, but are not individually significant biological regulators.
随着我们不断发现 RNA 的新调控作用，一个主题逐渐显现，即调控可能不是通过特定 RNA 的作用来介导的，就像人们通常认为的调控因子和靶标那样，而是通过许多 RNA 的集体性质来实现的，每个 RNA 都对调控负担做出微小的贡献。这种机制被称为“群体控制”，可能广泛适用于 miRNA 和结合并调节蛋白活性的 RNA。这为我们提供了一种思考 RNA 如何作为生物调节剂发挥作用的替代方式，并对理解生物系统以及解释结果产生影响，因为在这些结果中，“群体”中的个别成员在过表达时可以复制群体的效应，但它们本身并不是重要的生物学调控因子。
