Gerasimova E N, Levachev M M, Perova N V, Nikitin Iu P, Ozerova I N
Vopr Med Khim. 1986 Mar-Apr;32(2):66-72.
Contents of cholesterol, triglycerides, high density lipoproteins (HDL) cholesterol as well as phospholipid and fatty acid compositions of phosphatidyl cholines and sphingomyelins in low density lipoproteins (LDL) were studied in blood plasma of Chukot aborigenes--Eskimos as compared with Moscow inhabitants. In Eskimos content of HDL cholesterol was higher but concentration of cholesterol and triglycerides was lower in blood plasma. In LDL concentration of sphingomyelins was increased and fatty acid composition of phosphatidyl cholines and sphingomyelins was altered where amount of polyunsaturated fatty acids was elevated (20:5 + 22:5 + 22:6). The specific characteristics of the LDL phospholipids observed in Eskimos might be responsible for the higher liquid properties of the surface monolayer in the lipoproteins; this alteration might be important for the lipoprotein properties and transformation as well as for the properties of membrane-bound enzymes, for synthesis of thromboxane and prostacyclins.
对楚科奇原住民——爱斯基摩人的血浆与莫斯科居民的血浆进行了比较研究，分析了低密度脂蛋白（LDL）中胆固醇、甘油三酯、高密度脂蛋白（HDL）胆固醇的含量，以及磷脂酰胆碱和鞘磷脂的磷脂和脂肪酸组成。爱斯基摩人的血浆中HDL胆固醇含量较高，但胆固醇和甘油三酯浓度较低。LDL中鞘磷脂浓度升高，磷脂酰胆碱和鞘磷脂的脂肪酸组成发生改变，多不饱和脂肪酸（20:5 + 22:5 + 22:6）含量增加。在爱斯基摩人身上观察到的LDL磷脂的特定特征可能导致脂蛋白表面单层具有更高的流动性；这种改变可能对脂蛋白的性质和转化以及膜结合酶的性质、血栓素和前列环素的合成具有重要意义。
