Kolygin B A, Bulovskaia L N, Nevolin-Lopatin A M, Safonova S A
Vopr Onkol. 1986;32(4):52-7.
Examination of a healthy European population showed 60% to be "slow" acetylators and 40% "rapid" ones. A similar distribution was established in pediatric controls. Among children with Hodgkin's disease, there were 4.1 times more slow acetylators. N-acetyltransferase activity was found to increase with tumor advancement. Conversion of acetylation pattern was observed in pediatric patients with Hodgkin's disease.
对健康欧洲人群的检测显示，60%为“慢”乙酰化者，40%为“快”乙酰化者。在儿科对照人群中也确立了类似的分布。在患有霍奇金病的儿童中，慢乙酰化者的数量是前者的4.1倍。发现N - 乙酰转移酶活性随肿瘤进展而增加。在患有霍奇金病的儿科患者中观察到了乙酰化模式的转变。
