多学科康复干预对关节挛缩动物模型的活动能力和血液动力学的影响。

Multidisciplinary rehabilitation intervention on mobility and hemodynamics of joint contracture animal model.

机构信息

Nursing School of Xinjiang Medical University, Urumqi, 830011, China.

Xinjiang Agricultural University, Urumqi, 830052, China.

出版信息

J Orthop Surg Res. 2023 Apr 13;18(1):300. doi: 10.1186/s13018-023-03768-8.

DOI:10.1186/s13018-023-03768-8

PMID:37055802

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10100420/

Abstract

BACKGROUND

Joint contracture causes a decrease in range of motion (ROM), which severely affects activities of daily living of patients. We have investigated the effectiveness of a multidisciplinary rehabilitation on joint contracture by rat model.

METHODS

We used 60 Wistar rats in this study. The rats were divided into five groups as follows: group 1 was the normal control group; except the group 1, we created left hind limb knee joint contracture using Nagai method for other four groups. The joint contracture modeling group 2 was the model control group for monitoring the spontaneous recovery, and other three groups were given different rehabilitation treatments; for example, group 3 was treadmill running group; group 4 was medication group; group 5 was treadmill running plus medication group. The left hind limbs knee joint ROM and the femoral blood flow indicators (FBFI) including PS, ED, RI, and PI were measured right before and after the 4 weeks of rehabilitation.

RESULT

After 4 weeks of rehabilitation treatments, the measured values of ROM and FBFI are compared with the corresponding values of group 2. Firstly, we did not see clear difference in the values of ROM and FBFI for group 2 before and after 4 weeks spontaneous recovery. The improvement of left lower limb ROM for group 4 and group 5 as compared to the group 2 was statistically significant (p < 0.05), whereas a less recovery for group 3 was observed. However as compared to the group 1, we did not observe full recovery in ROM of group 4 and group 5 after 4 weeks of rehabilitation. The PS and ED level for rehabilitation treatment groups was significantly higher than those modeling ones (Tables 2, 3, Figs. 4, 5), while the RI and PI values show the contrary trends (Tables 4, 5, Figs. 6, 7).

CONCLUSION

Our results indicate that multidisciplinary rehabilitation treatments had a curative effect on both contracture of joints and the abnormal femoral circulations.

摘要

背景

关节挛缩会导致活动范围（ROM）减小，严重影响患者的日常生活活动。我们通过大鼠模型研究了多学科康复对关节挛缩的效果。

方法

本研究使用 60 只 Wistar 大鼠。除第 1 组为正常对照组外，其余大鼠均采用 Nagai 法建立左后肢膝关节挛缩模型。第 2 组为模型对照组，用于监测自发恢复情况，其余 3 组给予不同的康复治疗，如第 3 组为跑步机跑步组；第 4 组为药物治疗组；第 5 组为跑步机跑步加药物治疗组。在康复治疗前和治疗 4 周后测量左后肢膝关节 ROM 和股血流指标（PS、ED、RI、PI）。

结果

经过 4 周的康复治疗，将 ROM 和 FBFI 的测量值与第 2 组的相应值进行比较。首先，我们没有看到第 2 组在 4 周自发恢复前后 ROM 和 FBFI 值有明显差异。与第 2 组相比，第 4 组和第 5 组左下肢 ROM 的改善具有统计学意义（p<0.05），而第 3 组的恢复较差。然而，与第 1 组相比，我们没有观察到第 4 组和第 5 组在康复 4 周后 ROM 完全恢复。康复治疗组的 PS 和 ED 水平明显高于模型组（表 2、3、图 4、5），而 RI 和 PI 值则呈现相反的趋势（表 4、5、图 6、7）。