State Key Laboratory of Pharmaceutical Biotechnology, Medical School & School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Institute of Drug R&D, Nanjing University, Nanjing, 210093, China.
Endocr Metab Immune Disord Drug Targets. 2023;23(10):1340-1353. doi: 10.2174/1871530323666230413112614.
NPC2 is well known as a player for cholesterol transport. However, the biological role of NPC2 in cancer development and therapy is far from clear.
Here, we explore the potential role of NPC2 in prognosis and immunotherapy across multiple cancer types by integrating RNA-seq data from TCGA and GTEx, protein data from CPTAC, and multiple web analysis databases.
Expression depiction between tumour and normal tissues indicated that NPC2 is overexpressed in the majority of the most common cancer types, including glioblastoma and pancreatic cancer, two cancers mostly difficult to diagnose and treat.
Cancer stemness in glioblastoma is negatively associated with NPC2 level. NPC2 expression is positively correlated with immune cell infiltration and the expression of several immune checkpoints. IDH1 mutation in GBM is negatively correlated with NPC2 level, while a positive correlation has been found between TP53 mutation and NPC2 expression in pancreatic cancer. NPC2 is also correlated with levels of serum biomarkers used for diagnosis of pancreatic cancer.
NPC2 是众所周知的胆固醇转运蛋白。然而，NPC2 在癌症发展和治疗中的生物学作用还远不清楚。
通过整合 TCGA 和 GTEx 的 RNA-seq 数据、CPTAC 的蛋白质数据以及多个网络分析数据库，我们探索了 NPC2 在多种癌症类型中的预后和免疫治疗中的潜在作用。
肿瘤组织和正常组织之间的表达描述表明，NPC2 在大多数最常见的癌症类型中过度表达，包括胶质母细胞瘤和胰腺癌，这两种癌症大多难以诊断和治疗。
胶质母细胞瘤中的癌症干细胞与 NPC2 水平呈负相关。NPC2 的表达与免疫细胞浸润和几个免疫检查点的表达呈正相关。GBM 中的 IDH1 突变与 NPC2 水平呈负相关，而在胰腺癌中，TP53 突变与 NPC2 表达呈正相关。NPC2 还与用于诊断胰腺癌的血清生物标志物的水平相关。
