非外泌体和外泌体非编码 RNA 在心肌梗死调控机制及诊断生物标志物中的潜在作用。
Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction.
机构信息
Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
出版信息
J Zhejiang Univ Sci B. 2023 Apr 15;24(4):281-300. doi: 10.1631/jzus.B2200459.
Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and "pre-necrotic" biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.
非外泌体非编码 RNA（non-exo-ncRNAs）和外泌体 ncRNAs（exo-ncRNAs）与心肌梗死（MI）的病理发展有关。因此，本分析性综述概述了目前关于血浆非外泌体/外泌体 ncRNAs 在 MI 中作用的研究。我们通过生物信息学分析总结了 ncRNAs 的特征和关键作用，并揭示了它们新的生物学相关性。具体贡献如下：（1）我们全面描述了非外泌体/exo-ncRNAs 用于 MI 的表达谱、竞争性内源 RNA（ceRNA）网络和“坏死前”生物标志物；（2）功能富集分析表明，ncRNAs 的靶基因富集在凋亡信号通路的调节和细胞对化学应激的反应等过程中；（3）我们提出了非外泌体/exo-ncRNAs 在 MI 中的作用机制、病理生理学和生物标志物作用的最新和全面的观点，从而为 MI 的临床管理提供了理论依据。
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