Xie Luhan, Zhang Qingqing, Mao Jun, Zhang Jun, Li Lianhong
Department of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Department of Teaching Affairs, Dalian Medical University, Dalian, China.
Front Cell Dev Biol. 2021 Sep 16;9:680713. doi: 10.3389/fcell.2021.680713. eCollection 2021.
In recent years, long non-coding RNAs (lncRNAs) have been demonstrated to be associated with many physiological and pathological processes in cardiac. Recent studies have shown that lncRNAs are expressed dynamically in cardiovascular diseases and participate in regulation through a variety of molecular mechanisms, which have become a critical part of the epigenetic and transcriptional regulatory pathways in heart development, as well as the initiation and progress of myocardial infarction. In this review, we summarized some current research about the roles of lncRNAs in heart development and myocardial infarction, with the emphasis on molecular mechanisms of pathological responses, and highlighted their functions in the secondary changes of myocardial infarction. We also discussed the possibility of lncRNAs as novel diagnostic biomarkers and potential therapeutic targets for myocardial infarction.
近年来，长链非编码RNA（lncRNAs）已被证明与心脏的许多生理和病理过程相关。最近的研究表明，lncRNAs在心血管疾病中动态表达，并通过多种分子机制参与调控，这已成为心脏发育以及心肌梗死发生和进展过程中表观遗传和转录调控途径的关键部分。在本综述中，我们总结了目前关于lncRNAs在心脏发育和心肌梗死中作用的一些研究，重点关注病理反应的分子机制，并强调了它们在心肌梗死继发性变化中的功能。我们还讨论了lncRNAs作为心肌梗死新型诊断生物标志物和潜在治疗靶点的可能性。
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