Trevisan Giovani, Magstadt Drew, Woods Amy, Sparks Joel, Zeller Michael, Li Ganwu, Krueger Karen M, Saxena Anugrah, Zhang Jianqiang, Gauger Phillip C
Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, United States.
AMVC, Frankfort, IN, United States.
Front Vet Sci. 2023 Mar 28;10:1149293. doi: 10.3389/fvets.2023.1149293. eCollection 2023.
A porcine reproductive and respiratory syndrome virus (PRRSV) type 2 (PRRSV-2) isolate was obtained from lung samples collected from a 4.5-month-old pig at a wean-to-finish site in Indiana, USA, although no gross or microscopic lesions suggestive of PRRSV infection were observed in the lung tissue. Phylogenetic and molecular evolutionary analyses based on the obtained virus sequences indicated that PRRSV USA/IN105404/2021 was a natural recombinant isolate from Ingelvac PRRS MLV and Prevacent PRRS, which are PRRSV-2-modified live virus vaccines commercially available in the United States. This study is the first to report the detection of a PRRSV-2 recombinant strain consisting entirely of two modified live virus vaccine strains under field conditions. Based on clinical data and the absence of lung lesions, this PRRSV-2 recombinant strain was not virulent in swine, although its pathogenicity needs to be confirmed by clinical trials.
一株2型猪繁殖与呼吸综合征病毒（PRRSV-2）分离株，是从美国印第安纳州一个断奶至育肥猪场的一头4.5月龄猪的肺样本中获得的，尽管在肺组织中未观察到提示PRRSV感染的大体或微观病变。基于获得的病毒序列进行的系统发育和分子进化分析表明，PRRSV USA/IN105404/2021是一种来自Ingelvac PRRS MLV和Prevacent PRRS的天然重组分离株，这两种都是在美国可商购的PRRSV-2改良活病毒疫苗。本研究首次报道了在田间条件下检测到一种完全由两种改良活病毒疫苗株组成的PRRSV-2重组毒株。基于临床数据和肺部无病变情况，该PRRSV-2重组毒株对猪无致病性，尽管其致病性需要通过临床试验来证实。
