St Peter Deidre M, Steger Jennifer S, Patnaik Jennifer L, Davis Nicole, Kahook Malik Y, Seibold Leonard K
Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Nanodropper, Inc, Rochester, MN, USA.
Med Devices (Auckl). 2023 Apr 6;16:71-79. doi: 10.2147/MDER.S397654. eCollection 2023.
To determine the drop volume and total number of dispensed drops using the Nanodropper eyedrop bottle adaptor (Nanodropper, Inc.) compared to drops dispensed from stock bottles to potentially limit ocular toxicity of these eyedrops and prolong bottle use.
Six topical ocular hypotensive medications (5 solutions, 1 suspension), one steroid (suspension) and two artificial tears emulsions were selected for this study. An analytical balance was used to determine the mass per 10 drops with and without the volume-reducing adaptor and repeated until the bottles were completely emptied. The density of each product was determined using the calculated density. The average drop volume and number of drops per bottle for the nine medications were compared with and without the adaptor with paired t-testing.
When all medications were assessed, the drops delivered with the adaptor were 62.1% smaller than eyedrops administered from standard bottles. Compared to stock bottle eyedrops, which had a mean volume of 39.8 ± 2.1 μL, the adaptor resulted in drops with a mean volume of 15.1 ± 1.0 μL, p<0.0001. The adaptor delivered 2.6x the number of drops dispensed from a standard 2.5 mL bottle (184.1 ± 15.1 drops with adaptor and 69.8 ± 4.9 drops from stock bottle, p<0.0001).
The Nanodropper eyedrop bottle adaptor can significantly reduce drop volume and increase the overall number of drops dispensed compared with stock eyedrop bottles. Further studies are needed to elucidate the clinical impact of utilizing decreased drop volume with direct comparison to current standards of care.
使用纳米滴管眼药水瓶适配器（纳米滴管公司）测定滴液体积和滴出的总滴数，并与从原装瓶中滴出的液滴进行比较，以潜在地限制这些眼药水的眼毒性并延长瓶子的使用时间。
本研究选择了六种局部降眼压药物（5种溶液，1种混悬液）、一种类固醇（混悬液）和两种人工泪液乳剂。使用分析天平测定有无减少体积适配器时每10滴的质量，并重复此操作直至瓶子完全排空。使用计算出的密度确定每种产品的密度。采用配对t检验比较了使用和不使用适配器时九种药物的平均滴液体积和每瓶滴数。
在评估所有药物时，使用适配器滴出的液滴比从标准瓶中滴出的眼药水小62.1%。与平均体积为39.8±2.1μL的原装瓶眼药水相比，适配器使液滴的平均体积为15.1±1.0μL，p<0.0001。适配器滴出的滴数是标准2.5 mL瓶滴出滴数的2.6倍（使用适配器时为184.1±15.1滴，原装瓶为69.8±4.9滴，p<0.0001）。
与原装眼药水瓶相比，纳米滴管眼药水瓶适配器可显著减少滴液体积并增加滴出的总滴数。需要进一步研究以阐明与当前护理标准直接比较时，使用减少的滴液体积的临床影响。
