肝豆状核变性脑萎缩的线性测量及临床相关性研究
A study of linear measurement and clinical correlation of brain atrophy in Wilson's disease.
作者信息
Wang Yun, Xuan Hongxia, Zhao Tun, Li Xiaodong, Li Shujuan, Hu Wenli
机构信息
Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Hongda Hospital, Jiamusi University, Jiamusi, China.
出版信息
Front Hum Neurosci. 2023 Mar 28;17:1142082. doi: 10.3389/fnhum.2023.1142082. eCollection 2023.
BACKGROUND
The aim of this study was to explore the clinical relevance of linear measures of Wilson's disease (WD).
METHODS
Relative values of brain atrophy in 30 patients with WD and 30 healthy volunteers were measured and compared using a manual measurement method. Linear measurement indicators of brain atrophy in patients with and without mental disorders were also compared. In addition, correlations of patients' age, disease duration, and Unified Wilson's Disease Rating Scale (UWDRS) scores with brain atrophy indicators were determined.
RESULTS
The results showed that the e-value, Huckman number, Evans index, and lateral ventricular body index were higher in the WD group compared with the control group. The age of patients with WD was negatively correlated with the -value and significantly positively correlated with the brainstem index. WD duration was prominently positively correlated with the d-value and negatively correlated with the -value. In addition, neurological function scores were significantly positively correlated with the c-value, -value, caudate nucleus index, Huckman number, Evans index, and lateral ventricular body index. By contrast, patients with psychiatric symptoms had a higher a-value and fourth ventricular index than those without psychiatric symptoms.
CONCLUSION
Therefore, it can be concluded that patients with WD and those with psychiatric symptoms have more severe brain atrophy compared to normal subjects. The patient's age, disease duration, and neurological function scores were positively correlated with the severity of brain atrophy.
背景
本研究的目的是探讨肝豆状核变性（WD）线性测量指标的临床相关性。
方法
采用手工测量方法，对30例WD患者和30名健康志愿者的脑萎缩相对值进行测量和比较。还比较了有精神障碍和无精神障碍患者的脑萎缩线性测量指标。此外，确定患者年龄、病程和统一肝豆状核变性评定量表（UWDRS）评分与脑萎缩指标的相关性。
结果
结果显示，与对照组相比，WD组的e值、赫克曼数、埃文斯指数和侧脑室体指数更高。WD患者的年龄与e值呈负相关，与脑干指数呈显著正相关。WD病程与d值显著正相关，与e值负相关。此外，神经功能评分与c值、e值、尾状核指数、赫克曼数、埃文斯指数和侧脑室体指数显著正相关。相比之下，有精神症状的患者比无精神症状的患者a值和第四脑室指数更高。
结论
因此，可以得出结论，与正常受试者相比，WD患者和有精神症状的患者脑萎缩更严重。患者的年龄、病程和神经功能评分与脑萎缩严重程度呈正相关。
Zotero 插件