心肌梗死后纤维化：病理生理学、检查与干预
Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention.
作者信息
Yin Xiaoying, Yin Xinxin, Pan Xin, Zhang Jingyu, Fan Xinhui, Li Jiaxin, Zhai Xiaoxuan, Jiang Lijun, Hao Panpan, Wang Jiali, Chen Yuguo
机构信息
Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China.
出版信息
Front Pharmacol. 2023 Mar 28;14:1070973. doi: 10.3389/fphar.2023.1070973. eCollection 2023.
Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and extracellular matrix collagen deposition are the hallmarks of cardiac fibrosis, which are modulated by multiple signaling pathways and various types of cells in time-dependent manners. Our understanding of the development of cardiac fibrosis after MI has evolved in basic and clinical researches, and the regulation of fibrotic remodeling may facilitate novel diagnostic and therapeutic strategies, and finally improve outcomes. Here, we aim to elaborate pathophysiology, examination and intervention of cardiac fibrosis after MI.
心脏纤维化在心肌梗死（MI）后的心脏组织稳态和修复中起着不可或缺的作用。心脏成纤维细胞向肌成纤维细胞的分化以及细胞外基质胶原蛋白的沉积是心脏纤维化的标志，它们受到多种信号通路和各类细胞的时间依赖性调控。我们对心肌梗死后心脏纤维化发展的认识在基础和临床研究中不断演变，而对纤维化重塑的调控可能有助于制定新的诊断和治疗策略，并最终改善预后。在此，我们旨在阐述心肌梗死后心脏纤维化的病理生理学、检查方法及干预措施。
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