Pouraliakbar Hamidreza, Abouie Abolfazl, Ziaeifar Elham, Rakhshankhah Nima, Shabestari Abbas Arjmand, Rabiei Parham, Mohebbi Bahram, Alemzade-Ansari Mohammad Javad, Mahdieh Nejat
Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran.
Department of Radiology, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Pol J Radiol. 2023 Mar 18;88:e141-e148. doi: 10.5114/pjr.2023.126084. eCollection 2023.
This study aimed to examine the relationship of perivascular adipose tissue (PVAT) stranding in coronary computed tomography angiography (CCTA) with high-sensitivity C-reactive protein (hsCRP) and the determinants of PVAT stranding in coronary artery disease (CAD) patients.
This retrospective cross-sectional study was done by collecting data from CAD patients who were referred to Rajaie Cardiovascular Centre between January 2018 and September 2020, with CCTA and hsCRP test 72 hours apart from the CCTA. PVAT stranding was defined as irregular obscuration of PVAT adjacent to the coronary arteries. An attempt was made to find a correlation between included variables and PVAT stranding by comparing them between 2 groups: patients with and without PVAT stranding.
From 92 patients, 31 participants had PVAT stranding, and statistically significant higher levels of hsCRP were detected in them (p = 0.007). We demonstrated significantly higher prevalence of history of hyperlipidaemia (OR = 3.83, p = 0.029), high-risk plaque features (OR = 11.80, p = 0.015), and obstructive coronary luminal stenosis (OR = 3.25, p = 0.025) in patients with PVAT stranding. Also, significantly higher PVAT attenuation was detected in patients with PVAT stranding (p < 0.001) independently from mean attenuation of epicardial fat.
PVAT stranding could be used as a novel non-invasive marker in CCTA of CAD patients. More studies focusing on patient outcomes are required to better evaluate the reliability and prognostic value of this marker.
本研究旨在探讨冠状动脉计算机断层扫描血管造影（CCTA）中血管周围脂肪组织（PVAT）条索状改变与高敏C反应蛋白（hsCRP）的关系，以及冠心病（CAD）患者PVAT条索状改变的决定因素。
本回顾性横断面研究通过收集2018年1月至2020年9月转诊至拉贾伊心血管中心的CAD患者的数据进行，这些患者接受了CCTA检查，并在CCTA检查72小时后进行了hsCRP检测。PVAT条索状改变定义为冠状动脉相邻PVAT的不规则模糊。通过比较两组患者（有和无PVAT条索状改变）的纳入变量，试图找出它们与PVAT条索状改变之间的相关性。
在92例患者中，31例有PVAT条索状改变，且检测到他们的hsCRP水平在统计学上显著更高（p = 0.007）。我们证明，有PVAT条索状改变的患者中高脂血症病史（OR = 3.83，p = 0.029）、高危斑块特征（OR = 11.80，p = 0.015）和阻塞性冠状动脉管腔狭窄（OR = 3.25，p = 0.025）的患病率显著更高。此外，独立于心包脂肪的平均衰减，有PVAT条索状改变的患者中PVAT衰减也显著更高（p < 0.001）。
PVAT条索状改变可作为CAD患者CCTA中的一种新型非侵入性标志物。需要更多关注患者预后的研究来更好地评估该标志物的可靠性和预后价值。
