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[成人灭活流感疫苗有效性评估]

[Assessment of the effectiveness of inactivated influenza vaccines for adults].

作者信息

Ignat'eva G S, Shadrin A S, Maksakova V L, Efremov B V, Rudenko L G

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1986 Mar(3):8-10.

PMID:3705814
Abstract

In 9 controlled epidemiological observations (1977-1984) the effectiveness of modern Soviet whole-virion vaccines was studied in organized groups of adults and at industrial enterprises. During the epidemic outbreaks of influenza of different etiology and intensity morbidity rate in influenza and acute respiratory diseases was shown to decrease 1.1-2.2 times among the vaccinees, depending on the correspondence of epidemic and vaccine influenza strains. The absence of influenza virus B in inactivated influenza vaccines was the reason for their low effectiveness during influenza outbreaks of mixed etiology B + A (H1N1).

摘要

在9项对照流行病学观察研究(1977 - 1984年)中,对成人群体及工业企业中现代苏联全病毒疫苗的有效性进行了研究。在不同病因和强度的流感疫情爆发期间,接种疫苗者的流感及急性呼吸道疾病发病率降低了1.1至2.2倍,这取决于流行毒株与疫苗流感毒株的匹配程度。在B + A(H1N1)混合型病因的流感疫情期间,灭活流感疫苗中不含B型流感病毒是其有效性较低的原因。

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