Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, PO Box 450, 405 30, Gothenburg, Sweden.
Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Med Oncol. 2023 Apr 14;40(5):148. doi: 10.1007/s12032-023-01989-9.
The superiority of oral cryotherapy (OC) for prevention of chemotherapy-induced oral mucositis (OM) has been demonstrated in several trials. In clinical settings, cooling is usually initiated prior to the chemotherapy infusion. It then continues during the infusion, and for a period after the infusion has been completed. While the cooling period post-infusion depends on the half-life of the chemotherapeutic drug, there is no consensus on when cooling should be initiated prior to the infusion. The lowest achieved temperature in the oral mucosa is believed to provide the best condition for OM prevention. Given this, it was of interest to investigate when along the course of intraoral cooling this temperature is achieved. In total, 20 healthy volunteers participated in this randomized crossover trial. Each subject attended three separate cooling sessions of 30 min each, with ice chips (IC) and the intraoral cooling device (ICD) set to 8 and 15 °C, respectively. At baseline and following 5, 10, 15, 20 and 30 min of cooling, intraoral temperatures were registered using a thermographic camera. The greatest drop in intraoral temperature was seen after 5 min of cooling with IC, ICD and ICD, respectively. A statistically significant difference, corresponding to 1.4 °C, was seen between IC and the ICD (p < 0.05). The intraoral temperature further declined throughout the 30 min of cooling, showing an additional temperature reduction of 3.1, 2.2, and 1.7 °C for IC, ICD and ICD, respectively.
口腔冷冻疗法（OC）在预防化疗引起的口腔黏膜炎（OM）方面具有优势，这已在多项试验中得到证实。在临床环境中，通常在化疗输注前开始冷却。然后在输注期间和输注完成后继续进行冷却。虽然输注后冷却期取决于化疗药物的半衰期，但对于在输注前何时开始冷却尚未达成共识。人们认为，口腔黏膜中达到的最低温度为 OM 预防提供了最佳条件。有鉴于此，研究在口腔内冷却过程中何时达到该温度很有意思。总共有 20 名健康志愿者参加了这项随机交叉试验。每个受试者参加了三个单独的 30 分钟冷却疗程，冰屑（IC）和口腔内冷却装置（ICD）分别设置为 8°C 和 15°C。在基线和冷却 5、10、15、20 和 30 分钟后，使用热成像相机记录口腔内温度。使用 IC、ICD 和 ICD 冷却 5 分钟后，口腔内温度下降最大。IC 和 ICD 之间存在统计学上显著差异，相差 1.4°C（p<0.05）。在 30 分钟的冷却过程中，口腔内温度进一步下降，IC、ICD 和 ICD 分别显示出额外的 3.1°C、2.2°C 和 1.7°C 的温度降低。
