Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, PO Box 450, 405 30, Göteborg, Sweden.
BMC Oral Health. 2023 Sep 8;23(1):654. doi: 10.1186/s12903-023-03317-z.
Cryotherapy, using ice chips (IC) is an effective strategy to prevent chemotherapy-induced oral mucositis (OM) in selected cancer patient cohorts. However, although effective, use of IC may cause adverse reactions, e.g., nausea, numbness, and shooting pain in the teeth, which could have an adverse impact on the medical treatment. Furthermore, IC requires water of good quality to minimize risk of serious systemic infections. To eliminate these disadvantages, novel cooling devices have emerged as alternative cooling modalities. Thus, the aim was to evaluate the efficacy and tolerability profile of extraoral cooling for intraoral temperature reduction.
This experimental pilot study was conducted at the Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. In total, six healthy volunteers were enrolled in this study. At baseline and following 30-, and 60 min of cooling with the extraoral cooling device, intraoral mucosal temperatures were measured using a thermographic camera, and a questionnaire related to tolerability was completed.
Following 30-, and 60 min of cooling, the intraoral temperature decreased with 2.0 °C and 2.3 °C, respectively. Extraoral cooling was well tolerated, and all subjects endured the entire cooling session of 60 min.
Extraoral cooling reduces intraoral mucosal temperatures and is a well-tolerated cooling modality.
冷冻疗法，即使用冰屑（IC），是预防特定癌症患者群体发生化疗诱导性口腔黏膜炎（OM）的有效策略。然而，尽管有效，但使用 IC 可能会引起不良反应，例如恶心、麻木和牙齿刺痛，这可能会对治疗产生不利影响。此外，IC 需要使用优质水，以最大限度地降低发生严重全身感染的风险。为了消除这些缺点，新型冷却装置已成为替代冷却方式。因此，本研究旨在评估口腔外冷却降低口腔内温度的疗效和耐受性。
本实验性初步研究在瑞典哥德堡市萨赫勒格伦斯卡学院牙学院的牙科学院进行。共有 6 名健康志愿者参与了本研究。在基线时以及使用口腔外冷却装置冷却 30 和 60 分钟后，使用热成像摄像机测量口腔黏膜内温度，并完成与耐受性相关的问卷调查。
冷却 30 和 60 分钟后，口腔内温度分别下降了 2.0°C 和 2.3°C。口腔外冷却耐受性良好，所有受试者均能耐受整个 60 分钟的冷却过程。
口腔外冷却可降低口腔黏膜内温度，是一种耐受性良好的冷却方式。
