Department of Organic Synthesis and Process Chemistry, CSIR - Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
J Org Chem. 2023 May 5;88(9):5772-5779. doi: 10.1021/acs.joc.3c00228. Epub 2023 Apr 14.
A facile double oxidative annulation of (en-3-yn-1-yl)phenylbenzamides was developed allowing us to synthetize fused tetracyclic compounds. Under copper catalysis, the reaction proceeds with high efficiency and leads to new indolo[1,2-]quinolines via a decarbonylative double oxidative annulation. On the other hand, under ruthenium catalysis, new isoquinolin-1[2]-ones were obtained via a double oxidative annulation.
开发了一种简便的（en-3-yn-1-yl）苯基苯甲酰胺的双氧化环化反应，使我们能够合成稠合的四环化合物。在铜催化下，该反应高效进行，通过脱羰双氧化环化生成新的吲哚并[1,2-]喹啉。另一方面，在钌催化下，通过双氧化环化得到新的异喹啉-1[2]-酮。
