Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Chem Asian J. 2020 Apr 1;15(7):1052-1056. doi: 10.1002/asia.202000096. Epub 2020 Mar 12.
An effective and pragmatic strategy for the synthesis of structurally diverse indolo[2,3-c]isoquinolin-5-ones has been developed via a Rh(III)-catalyzed C-H activation and [4+2] annulation reaction of N-methoxybenzamides and 3-diazoindolin-2-imines. The reaction involves the efficient formation of two new (one C-C and one C-N) bonds under operationally simple conditions and has the benefits of a broad substrate scope.
一种有效且实用的策略被开发出来，用于通过 Rh(III)催化的 N-甲氧基苯甲酰胺和 3-重氮吲哚啉-2-亚胺的 C-H 活化和[4+2]环加成反应来合成结构多样的吲哚并[2,3-c]异喹啉-5-酮。该反应在操作简单的条件下高效地形成了两个新的（一个 C-C 和一个 C-N）键，具有广泛的底物范围的优点。
