Mautalen C, Reyes H R, Ghiringhelli G, Fromm G
Acta Endocrinol (Copenh). 1986 Apr;111(4):494-7. doi: 10.1530/acta.0.1110494.
The bone mineral content (BMC) of 35 patients with primary hyperparathyroidism (PHPT) was measured at the mid radius (95% cortical bone) by photon absorptiometry of a 241Am source. The majority of the patients had an overt disease of moderate to severe degree. Average serum calcium of the group was 12.3 mg/100 ml (range 10.6 to 18.0 mg/100 ml). The percentage of normality of the BMC was (Av +/- 1 SD) 75.1 +/- 13.0% for the whole group. The average increment of BMC in 14 patients 9 to 26 months after parathyroidectomy was 9.9%, with a wide dispersion. However a highly significant negative correlation (r: 0.83; P less than 0.01) was found between the initial bone mass and the percentage increment per month after surgery. No further gain was observed 2 years after parathyroidectomy except in one patient with an extremely severe bone loss. In spite of the gain obtained after surgery the bone mass remained markedly diminished in most patients showing that the cortical bone loss caused by PHPT is mainly irreversible.
采用241Am源光子吸收法对35例原发性甲状旁腺功能亢进症（PHPT）患者的桡骨中段（95%为皮质骨）骨矿物质含量（BMC）进行了测量。大多数患者患有中度至重度显性疾病。该组患者的平均血清钙为12.3mg/100ml（范围为10.6至18.0mg/100ml）。整个组BMC的正常百分比为（平均值±1标准差）75.1±13.0%。14例患者在甲状旁腺切除术后9至26个月，BMC的平均增幅为9.9%，离散度较大。然而，发现初始骨量与术后每月的增幅百分比之间存在高度显著的负相关（r：0.83；P<0.01）。甲状旁腺切除术后2年，除1例骨丢失极为严重的患者外，未观察到进一步的骨量增加。尽管术后骨量有所增加，但大多数患者的骨量仍明显减少，这表明PHPT导致的皮质骨丢失主要是不可逆的。
