Martin P, Bergmann P, Gillet C, Fuss M, Kinnaert P, Corvilain J, van Geertruyden J
Arch Intern Med. 1986 Apr;146(4):689-91.
Bone mineral content of the radius in 30 patients with primary hyperparathyroidism was determined by single-photon absorptiometry before and one year after the removal of a parathyroid adenoma. When compared with normal age- and sex-matched subjects, preoperative bone mineral content was decreased by more than 1 SD in 24 patients 3 cm from the styloid apophysis (distal site) and in 23 patients 8 cm from the styloid apophysis (proximal site). The decrease at the distal site, where there is more trabecular bone, was significantly greater than at the proximal site (74% +/- 13% of the normal mean vs 79% +/- 13%). Bone mineral content values were not different in the female and male populations. One year after surgery, the bone mineral content was significantly increased but was still lower than normal at both sites (81% and 84% of the normal mean, respectively). In some patients, seen up to three years after surgery, the bone mineral content remained lower than normal. We conclude that primary hyperparathyroidism causes an osteopenia that affects both cortical and trabecular bone and that is only partially reversible, even in the long term.
采用单光子吸收法测定了30例原发性甲状旁腺功能亢进患者切除甲状旁腺腺瘤前后桡骨的骨矿物质含量。与年龄和性别匹配的正常受试者相比，术前在距茎突骨骺3 cm处（远端部位）有24例患者、在距茎突骨骺8 cm处（近端部位）有23例患者的骨矿物质含量下降超过1个标准差。远端部位小梁骨较多，其骨矿物质含量下降幅度显著大于近端部位（分别为正常均值的74%±13%和79%±13%）。女性和男性人群的骨矿物质含量值无差异。术后1年，骨矿物质含量显著增加，但两个部位仍低于正常水平（分别为正常均值的81%和84%）。在术后长达3年的部分患者中，骨矿物质含量仍低于正常水平。我们得出结论，原发性甲状旁腺功能亢进会导致骨质减少，影响皮质骨和小梁骨，且即使长期来看也只是部分可逆。
