Goto S, Uhthoff H K
Acta Orthop Scand. 1986 Apr;57(2):149-53. doi: 10.3109/17453678609000890.
Fourteen spinal malformations were found in 328 spontaneously aborted human embryos and fetuses. Of these, 13 were investigated histologically and histomorphometrically and compared with 47 age- and stagematched normal specimens to document any possible relationship between spinal and notochordal malformations. Although six notochordal malformations, such as bifurcation, were found in 14 spinal malformations, the respective sites did not correspond. Abnormality of notochordal tissue--such as degeneration and delayed development, which was observed in nine of 14 spinal malformations--was not restricted to the site of the spinal malformation. Moreover, tissue changes responsible for spinal malformations usually did not occur in direct contact with the notochord. On the other hand, malformed notochords were found in normal specimens. We therefore were unable to confirm in human specimens that notochordal abnormalities induce spinal malformations, a fact well established in lower vertebrates.
在328例自然流产的人类胚胎和胎儿中发现了14例脊柱畸形。其中，对13例进行了组织学和组织形态计量学研究，并与47例年龄和发育阶段匹配的正常标本进行比较，以记录脊柱畸形与脊索畸形之间的任何可能关系。虽然在14例脊柱畸形中发现了6例脊索畸形，如分叉，但各自的部位并不对应。脊索组织的异常，如变性和发育延迟，在14例脊柱畸形中的9例中观察到，但并不局限于脊柱畸形的部位。此外，导致脊柱畸形的组织变化通常不与脊索直接接触。另一方面，在正常标本中也发现了畸形的脊索。因此，我们无法在人类标本中证实脊索异常会导致脊柱畸形，而这一事实在低等脊椎动物中已得到充分证实。
