Leyssac P P
Acta Physiol Scand. 1986 Feb;126(2):271-7. doi: 10.1111/j.1748-1716.1986.tb07814.x.
Free flow microperfusion (closed feedback loop) experiments in halothane-nitrous oxide-anaesthetized rats demonstrate two distinct oscillating TGF pressure responses to pertubations in early distal tubular flow. Flow rate changes of 2-8 nl min-1 induced a 0.02-0.03 Hz rhythm, while changes above 25 nl min-1 often induced a 0.17-0.18 Hz rhythm in proximal tubular pressures. Following interruption of microperfusion, the intratubular pressure showed an initial undershoot and a gradual oscillating return to the control level. Each nephron responded individually to systemic changes with oscillations differing in frequency, phase and amplitude from that of its neighbour. Postglomerular vascular pressure (PSV) oscillated synchronous with the proximal luminal pressure (PProx) of the same nephron; the amplitude of the PSV might be larger than that of the corresponding PProx. The PSV decreased by 2-3 mmHg as Henle loop flow was increased by 7 nl min-1. Furosemide (0.1-0.2 mM) in the microperfusate abolished the oscillations, and caused PSV and PProx to increase by 3-4 mmHg. This effect was rapidly reversible.
在氟烷-氧化亚氮麻醉的大鼠中进行的自由流动微灌注（闭环反馈）实验表明，早期远端肾小管流量的扰动会引起两种不同的振荡性TGF压力反应。2-8 nl min-1的流速变化会诱导出0.02-0.03 Hz的节律，而高于25 nl min-1的变化通常会在近端肾小管压力中诱导出0.17-0.18 Hz的节律。微灌注中断后，肾小管内压力显示出初始下冲，并逐渐振荡恢复到对照水平。每个肾单位对全身变化的反应都是独立的，其振荡的频率、相位和幅度与其相邻肾单位不同。肾小球后血管压力（PSV）与同一肾单位的近端管腔压力（PProx）同步振荡；PSV的幅度可能大于相应的PProx。当亨氏袢流量增加7 nl min-1时，PSV降低2-3 mmHg。微灌注液中的呋塞米（0.1-0.2 mM）消除了振荡，并使PSV和PProx增加3-4 mmHg。这种作用可迅速逆转。
