Holstein-Rathlou N H, Leyssac P P
Acta Physiol Scand. 1986 Mar;126(3):333-9. doi: 10.1111/j.1748-1716.1986.tb07824.x.
A highly sensitive oscillatory tubulo-glomerular feedback (TGF) response has previously been demonstrated in normotensive Sprague-Dawley rats. The purpose of the present study was to examine whether such as oscillating TGF-response could be elicited in Wistar-Kyoto rats (WKY) and genetically hypertensive rats (SHR) and furthermore if any differences in the TGF-response characteristics between SHR and WKY rats could be detected. The closed loop function of the TGF-system was studied. In 12-18-week-old WKY rats regular oscillations in the intratubular pressure occurred spontaneously. The median frequency were 29.7 mHz (range 20-46.7 mHz). In SHR rats, spontaneous oscillations also occurred, but these were highly irregular. Spontaneous oscillations were more frequent in WKY than in SHR (88% vs. 54%). In both strains, oscillations could be elicited by free flow microperfusion with artificial tubular fluid (ATF). When furosemide was added to the ATF in a concentration of 0.1 mM, the oscillations were abolished in both strains of rats. It is concluded that, in both strains of rats the oscillatory phenomena depend upon TGF activity. It is suggested that the irregular pattern of the oscillations observed only in SHR rats may represent a chaotic process.
先前已在正常血压的斯普拉格-道利大鼠中证实了高度敏感的振荡性肾小管-肾小球反馈（TGF）反应。本研究的目的是检验在Wistar-Kyoto大鼠（WKY）和遗传性高血压大鼠（SHR）中是否能引发这种振荡性TGF反应，此外是否能检测到SHR和WKY大鼠之间TGF反应特征的任何差异。研究了TGF系统的闭环功能。在12 - 18周龄的WKY大鼠中，肾小管内压力会自发出现规律性振荡。中位频率为29.7 mHz（范围为20 - 46.7 mHz）。在SHR大鼠中也会出现自发振荡，但这些振荡非常不规则。WKY大鼠中自发振荡比SHR大鼠更频繁（88%对54%）。在这两种品系中，用人工肾小管液（ATF）进行自由流微灌注均可引发振荡。当向ATF中加入浓度为0.1 mM的呋塞米时，两种品系大鼠的振荡均被消除。结论是，在两种品系大鼠中，振荡现象均依赖于TGF活性。有人提出，仅在SHR大鼠中观察到的振荡不规则模式可能代表一种混沌过程。
