Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India.
Department of Computer and Communication Engineering, Sri Sai Ram Institute of Technology, Chennai, Tamil Nadu, India.
Proc Inst Mech Eng H. 2023 May;237(5):529-541. doi: 10.1177/09544119231164713. Epub 2023 Apr 14.
Electrospinning is a versatile method which is used to synthesize nano/micro sized fibers under the influence of an electric field. Electrospun nanoscaffolds are one of the widely accepted platforms for cultivating soft and hard tissues as they create a perfect micro-environment for cell adhesion, proliferation and differentiation. Nanoscaffolds are widely used in the field of tissue engineering due to their versatility in aiding the growth of different types of cells and tissues for varied applications. The composition, molecular weight and structure of polymer used to fabricate nanoscaffold plays an important role in determining the size and strength of the nanofibers prepared. This review gives information about the background, process and different types of polymers used in electrospinning. Recent advances in culturing liver cells, osteoblasts, skin cells, neural cells and coronary artery smooth muscle cells on nanoscaffolds are also elucidated.
静电纺丝是一种通用的方法，在电场的影响下用于合成纳米/微米尺寸的纤维。静电纺纳米支架是一种被广泛认可的培养软硬组织的平台，因为它们为细胞黏附、增殖和分化创造了一个完美的微环境。由于纳米支架在促进不同类型细胞和组织生长方面的多功能性，它们在组织工程领域得到了广泛的应用。用于制备纳米支架的聚合物的组成、分子量和结构在很大程度上决定了所制备的纳米纤维的大小和强度。这篇综述介绍了静电纺丝的背景、过程和使用的不同类型的聚合物。还阐述了在纳米支架上培养肝细胞、成骨细胞、皮肤细胞、神经细胞和冠状动脉平滑肌细胞的最新进展。
