An Ziyu, Tian Jinfan, Zhao Xin, Liu Libo, Yang Xueyao, Zhang Mingduo, Zhang Lijun, Song Xiantao
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, China.
FEBS J. 2024 Sep;291(17):3753-3761. doi: 10.1111/febs.16798. Epub 2023 Apr 28.
Caveolae are intracellular vesicles with diameters ranging from 50 to 100 nm. The role of caveolins in mediating oxidative stress, autophagy, apoptosis, fibrosis, and vascular remodeling has attracted increasing attention in cardiovascular therapy. Several studies have suggested that caveolin could be a therapeutic target for the treatment of cardiac and/or vascular injury via several pathophysiological mechanisms. Despite substantial advances in our understanding of the basic biology of vesicles over the past decade, the relevance and specific role of these mechanisms in cardiovascular homeostasis remains ambiguous. Here, we review the macroscopic role of caveolins in protecting cardiac function and, at the microscopic level, examine possible cardioprotective caveolar mechanisms, including their antioxidative stress, antiapoptosis, autophagy-regulatory, antifibrosis, and angiogenesis-promoting properties. We believe that the role of caveolins in cardiac functioning has not been fully elucidated and is an important line of future research with several cardioprotective implications.
小窝是直径在50至100纳米之间的细胞内囊泡。小窝蛋白在介导氧化应激、自噬、凋亡、纤维化和血管重塑中的作用在心血管治疗中已引起越来越多的关注。多项研究表明，小窝蛋白可能是通过多种病理生理机制治疗心脏和/或血管损伤的治疗靶点。尽管在过去十年中我们对囊泡基础生物学的理解有了实质性进展，但这些机制在心血管稳态中的相关性和具体作用仍不明确。在此，我们综述小窝蛋白在保护心脏功能方面的宏观作用，并在微观层面研究可能的心脏保护小窝机制，包括其抗氧化应激、抗凋亡、自噬调节、抗纤维化和促血管生成特性。我们认为，小窝蛋白在心脏功能中的作用尚未完全阐明，是未来研究的一个重要方向，具有多种心脏保护意义。
