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疑似胸膜犬弓蛔虫病 1 例罕见报告。

A rare case of presumptive pleural toxocariasis.

机构信息

Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie Génétique, CHU de Lille, 1 Boulevard J. Leclercq, 59037, Lille Cedex, France.

Service de Pneumologie, CH Arras, Arras, France.

出版信息

Eur J Clin Microbiol Infect Dis. 2023 Jun;42(6):781-786. doi: 10.1007/s10096-023-04595-9. Epub 2023 Apr 15.

Abstract

Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis. Only six isolated cases of pleural toxocariasis have been reported in the literature. We describe a case of pleurisy with isolated eosinophilia varying between 600 and 1500/mm likely linked o presumptive toxocariasis in a 72-year-old patient. Our patient was admitted to hospital with severe dyspnoea, asthenia and diarrhoea. Imaging studies confirmed right unilateral pleurisy without any parenchymal involvement. Serology of serum and pleural fluid was positive for anti-Toxocara antibodies by ELISA and immunoblotting. Treatment by pleural drainage and anti-parasitic medication with albendazole for 8 days resulted in the resolution of symptoms. A decrease in the levels of polynuclear eosinophils and total IgE confirmed the clinical resolution. The presence of hypereosinophilia in pleural fluid should evoke a diagnosis of pleural toxocariasis. Clinical symptoms and imaging are non-specific, but positive serology for anti-Toxocara antibodies in serum and pleural fluid can confirm the diagnosis.

摘要

弓蛔虫病是一种世界性的寄生虫病,与猫弓首蛔虫或犬弓首蛔虫的污染有关。文献中仅报道了 6 例孤立性胸膜弓蛔虫病病例。我们描述了一例 72 岁患者的胸膜炎伴孤立性嗜酸性粒细胞增多症,嗜酸性粒细胞在 600 至 1500/mm 之间,可能与疑似弓蛔虫病有关。我们的患者因严重呼吸困难、乏力和腹泻而住院。影像学研究证实右侧单侧胸膜炎,无实质受累。血清和胸腔液的血清学通过 ELISA 和免疫印迹检测抗弓蛔虫抗体呈阳性。通过胸腔引流和用阿苯达唑进行 8 天的抗寄生虫治疗,症状得到缓解。嗜酸性粒细胞增多症和总 IgE 的水平降低证实了临床缓解。胸腔液中嗜酸性粒细胞增多症的存在应提示诊断为胸膜弓蛔虫病。临床症状和影像学表现是非特异性的,但血清和胸腔液中抗弓蛔虫抗体的阳性血清学可确认诊断。

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