Kwon Nam-Hee, Oh Mi-Jung, Lee Sang-Pyo, Lee Byung-Jae, Choi Dong-Chull
Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Ann Hematol. 2006 Apr;85(4):233-8. doi: 10.1007/s00277-005-0069-x. Epub 2006 Feb 7.
Toxocariasis is one of the causes of eosinophilia in peripheral blood and provokes eosinophilic infiltration in internal organs. Extended studies on the prevalence and clinical characteristics of toxocariasis have been rare. The aim of this study is to evaluate the prevalence of toxocariasis in unknown eosinophilia and to analyze the efficacy of toxocara enzyme-linked immunosorbent assay (ELISA). We evaluated patients presenting with peripheral blood eosinophilia (>500 cells/microl or > or =10% of white blood cell count). After checking drug histories and the presence of allergic diseases and parasitic infections, specific serum IgG antibody to Toxocara canis larval antigen was measured by ELISA. Liver and lung involvement was also evaluated. One-hundred and three patients were evaluated, and the mean age was 50.9 years old. Seventy patients (68.0%) were diagnosed as having toxocariasis. The patients who had a history of raw liver eating had a higher incidence, and the patients with liver involvement had higher serum eosinophil cationic protein values. The eosinophil count was normalized in 7 of 16 treated patients and in 25 of 54 untreated patients. The mean improvement duration was 12 months. We concluded that the prevalence of toxocariasis was high in patients with unknown eosinophilia, and the toxocara ELISA was essential for evaluation of the causes of unknown eosinophilia.
弓蛔虫病是外周血嗜酸性粒细胞增多的病因之一，可引起内脏器官嗜酸性粒细胞浸润。关于弓蛔虫病患病率和临床特征的广泛研究较为罕见。本研究旨在评估不明原因嗜酸性粒细胞增多症患者中弓蛔虫病的患病率，并分析犬弓蛔虫酶联免疫吸附测定（ELISA）的效果。我们评估了外周血嗜酸性粒细胞增多（>500个细胞/微升或>或=白细胞计数的10%）的患者。在检查用药史、过敏性疾病和寄生虫感染情况后，通过ELISA检测血清中针对犬弓蛔虫幼虫抗原的特异性IgG抗体。同时也评估了肝脏和肺部受累情况。共评估了103例患者，平均年龄为50.9岁。70例患者（68.0%）被诊断为患有弓蛔虫病。有生食肝脏史的患者发病率较高，肝脏受累患者的血清嗜酸性粒细胞阳离子蛋白值较高。16例接受治疗的患者中有7例嗜酸性粒细胞计数恢复正常，54例未接受治疗的患者中有25例恢复正常。平均改善持续时间为12个月。我们得出结论，不明原因嗜酸性粒细胞增多症患者中弓蛔虫病的患病率较高，犬弓蛔虫ELISA对于评估不明原因嗜酸性粒细胞增多症的病因至关重要。
