双歧杆菌 T37a 对 D-半乳糖诱导的小鼠体重减轻和衰老模型的抗氧化作用。
Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose.
机构信息
Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, Guangdong, China.
College of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
出版信息
BMC Microbiol. 2023 Apr 15;23(1):103. doi: 10.1186/s12866-023-02846-5.
BACKGROUND
Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose.
RESULTS
T37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver.
CONCLUSIONS
T37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.
背景
益生菌可以降低自由基清除率和氧化损伤，提高宿主细胞中关键抗氧化酶的活性。本研究旨在从婴儿粪便中分离双歧杆菌属，并研究双歧杆菌 T37a 对 D-半乳糖诱导的小鼠体重减轻和衰老模型的抗氧化作用。
结果
T37a 在 DPPH 测定和抗脂质过氧化试验中具有良好的抗氧化性能。与模型组相比，T37a 低剂量组显著提高了小鼠的胸腺指数以及 T-AOC 和 GSH-Px 的水平。T37a 高剂量组显著降低了小鼠的脾、肝指数和肝 MDA 水平，显著提高了肝 HDL-C 水平，降低了肝 LDL-C 水平。
结论
T37a 可能是一种具有抗氧化能力的抗衰老和减肥益生菌，有必要进一步研究 T37a 作为抗氧化剂的分子机制。
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