Alberti-Flor J J, de Medina M, Jeffers L, Schultz D R, Schiff E R
Am J Gastroenterol. 1986 May;81(5):325-8.
The concentration of immunoglobulins and immune complexes was determined in the serum and bile of four patients with primary sclerosing cholangitis, only one of whom had chronic ulcerative colitis, and in four postcholecystectomy control patients. The result of the immunoglobulin studies demonstrated increased serum levels of IgM in primary sclerosing cholangitis as compared to control patients. The IgG, IgA, and IgM in bile were all significantly elevated as compared to controls (p = 0.02). Immune complexes in bile and serum were also determined in both groups by the C1q and conglutinin binding assays. Immune complexes in bile were elevated in three of four of the patients with primary sclerosing cholangitis. These findings further characterize primary sclerosing cholangitis in terms of biliary immunoglobulins and immune complexes but do not resolve whether these changes are an epiphenomenon or reflect a primary role of immunoglobulins and immune complexes in the pathogenesis of this disorder.
测定了4例原发性硬化性胆管炎患者血清和胆汁中的免疫球蛋白及免疫复合物水平，其中仅1例患有慢性溃疡性结肠炎，同时测定了4例胆囊切除术后对照患者的相关指标。免疫球蛋白研究结果显示，与对照患者相比，原发性硬化性胆管炎患者血清IgM水平升高。与对照组相比，胆汁中的IgG、IgA和IgM均显著升高（p = 0.02）。两组均通过C1q和胶固素结合试验测定了胆汁和血清中的免疫复合物。原发性硬化性胆管炎患者中有3/4胆汁中的免疫复合物升高。这些发现进一步从胆汁免疫球蛋白和免疫复合物方面对原发性硬化性胆管炎进行了特征描述，但并未解决这些变化是一种附带现象还是反映了免疫球蛋白和免疫复合物在该疾病发病机制中的主要作用这一问题。
