Department of Child Health Care, Children's Hospital of Chongqing Medical University, Chongqing, China.
National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China.
Front Immunol. 2023 Mar 31;14:1153607. doi: 10.3389/fimmu.2023.1153607. eCollection 2023.
Although epidemiological trends of childhood food sensitization (FS) in IgE-mediated food allergy were reported in China, few studies have examined at changes in its risk factors.
To investigate the change in early-life risk factors associated with childhood food sensitization during 2009-2019 in China.
Data from two cross-sectional surveys conducted in 2009 and 2019 (401 and 513 children, respectively) were analyzed. The results of skin prick tests and information on food sensitization-related risk factors in children were summarized, including family history of atopic disease (FHA), demographic characteristics, method of delivery, feeding patterns, sibship size, pet ownership, and vitamin D supplementation. Binary logistic regression was used to calculate the odds ratio and the regression coefficient -value of risk factors in the 2009 and 2019 surveys separately. Then, coefficient -value differences between the two surveys were analyzed by the bdiff command in STATA to describe the change in risk factors over 10 years.
The 2009 survey revealed that FHA, age, only child, and feeding patterns were associated with food sensitization. The 2019 survey showed that food sensitization was affected by age, sex, and feeding patterns. However, from 2009 to 2019, the probability of food sensitization in the only-child group significantly increased by 226.0% (-value difference = 0.81, = 0.024) and decreased by 65.0% in female children (-value difference = -1.06, = 0.008). The effect of age on food sensitization decreased by 50.0% (-value difference = -0.69, < 0.001) over 10 years.
The effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009-2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.
http://www.chictr.org.cn/, identifier ChiCTR1900024338.
虽然中国有关于 IgE 介导的食物过敏儿童食物致敏（FS）的流行病学趋势的报道，但很少有研究调查其危险因素的变化。
调查 2009-2019 年中国儿童食物致敏早期生活相关危险因素的变化。
对 2009 年和 2019 年进行的两项横断面调查（分别为 401 名和 513 名儿童）的数据进行分析。总结了儿童皮肤点刺试验结果和与食物致敏相关的危险因素信息，包括特应性疾病家族史（FHA）、人口统计学特征、分娩方式、喂养方式、同胞数量、宠物拥有情况和维生素 D 补充情况。分别使用二项逻辑回归计算 2009 年和 2019 年调查中危险因素的比值比和回归系数-β值。然后，使用 STATA 中的 bdiff 命令分析两次调查之间的系数-β值差异，以描述 10 年来危险因素的变化。
2009 年的调查显示，FHA、年龄、独生子和喂养方式与食物致敏有关。2019 年的调查显示，年龄、性别和喂养方式影响食物致敏。然而，从 2009 年到 2019 年，独生子组食物致敏的概率显著增加了 226.0%（β 值差异=0.81，=0.024），女性儿童食物致敏的概率降低了 65.0%（β 值差异=-1.06，=0.008）。10 年来，年龄对食物致敏的影响降低了 50.0%（β 值差异=-0.69，<0.001）。
2009-2019 年期间，FHA 和常见生活方式因素对食物致敏的影响没有显著变化。然而，自 2009 年以来，人口统计学特征对食物致敏的影响发生了变化；即年龄较大、男性和独生子更有可能发生食物致敏，这在未来的流行病学调查中需要考虑。
http://www.chictr.org.cn/，标识符 ChiCTR1900024338。
Zotero 插件