新冠病毒病后相关多器官并发症或“长新冠”：文献综述与管理策略探讨的荟萃分析
Post-COVID-19-associated multiorgan complications or "long COVID" with literature review and management strategy discussion: A meta-analysis.
作者信息
Iqbal Phool, Ata Fateen, Chaudhry Hassan, Muthanna Bassam, Waqas Younas Hafiz, Munamm Syed Ata Ul, Sharma Rohit, Fadah Kahtan, Elazzazy Shereen, Hamad Anas, Said Abu Tabar Osama, Omar Nabil E
机构信息
Department of Internal Medicine New York Medical College/Metropolitan Hospital Center New York New York USA.
Department of Endocrinology Hamad Medical Corporation Doha Qatar.
出版信息
Health Sci Rep. 2023 Apr 14;6(4):e1211. doi: 10.1002/hsr2.1211. eCollection 2023 Apr.
OBJECTIVE
To investigate the post-COVID-19 long-term complications or long COVID of various organ systems in patients after 3 months of the infection, specifically before the Omicron variant, with comparative literature analysis.
METHODS
A systemic literature search and meta-analysis were conducted using multiple electronic databases (PubMed, Scopus, Cochrane library) with predefined search terms to identify eligible articles. Eligible studies reported long-term complications of COVID-19 infection before the Omicron variant infection. Case reports, case series, observational studies with cross-sectional or prospective research design, case-control studies, and experimental studies that reported post-COVID-19 complications were included. The complications reported after 3 months after the recovery from COVID-19 infection were included in the study.
RESULTS
The total number of studies available for analysis was 34. The effect size (ES) for neurological complications was 29% with 95% confidence interval (CI): 19%-39%. ES for psychiatric complications was 24% with 95% CI: 7%-41%. ES was 9% for cardiac outcomes, with a 95% CI of 1%-18%. ES was 22%, 95% CI: 5%-39% for the gastrointestinal outcome. ES for musculoskeletal symptoms was 18% with 95% CI: 9%-28%. ES for pulmonary complications was 28% with 95% CI: 18%-37%. ES for dermatological complications was 25%, with a 95% CI of 23%-26%. ES for endocrine outcomes was 8%, with a 95% CI of 8%-9%. ES size for renal outcomes was 3% with a 95% CI of 1%-7%. At the same time, other miscellaneous uncategorized outcomes had ES of 39% with 95% CI of 21%-57%. Apart from analyzing COVID-19 systemic complications outcomes, the ES for hospitalization and intensive care unit admissions were found to be 4%, 95% CI: 0%-7%, and 11% with 95% CI: 8%-14%.
CONCLUSION
By acquiring the data and statistically analyzing the post-COVID-19 complications during the prevalence of most virulent strains, this study has generated a different way of understanding COVID-19 and its complications for better community health.
目的
通过比较文献分析，调查新冠病毒感染3个月后（特别是在奥密克戎变异株出现之前）患者各器官系统的新冠后长期并发症或新冠长期症状。
方法
使用多个电子数据库（PubMed、Scopus、Cochrane图书馆），采用预定义的检索词进行系统的文献检索和荟萃分析，以确定符合条件的文章。符合条件的研究报告了奥密克戎变异株感染之前新冠病毒感染的长期并发症。纳入了病例报告、病例系列、采用横断面或前瞻性研究设计的观察性研究、病例对照研究以及报告新冠后并发症的实验性研究。研究纳入了新冠病毒感染康复3个月后报告的并发症。
结果
可供分析的研究总数为34项。神经并发症的效应量（ES）为29%，95%置信区间（CI）：19%-39%。精神并发症的ES为24%，95%CI：7%-41%。心脏结局的ES为9%，95%CI为1%-18%。胃肠道结局的ES为22%，95%CI：5%-39%。肌肉骨骼症状的ES为18%，95%CI：9%-28%。肺部并发症的ES为28%，95%CI：18%-37%。皮肤并发症的ES为25%，95%CI为23%-26%。内分泌结局的ES为8%，95%CI为8%-9%。肾脏结局的ES大小为3%，95%CI为1%-7%。同时，其他未分类的杂项结局的ES为39%，95%CI为21%-57%。除了分析新冠病毒的全身并发症结局外，住院和重症监护病房入院的ES分别为4%，95%CI：0%-7%，以及11%，95%CI：8%-14%。
结论
通过获取数据并对最具毒性毒株流行期间的新冠后并发症进行统计分析，本研究为更好地了解新冠病毒及其并发症、改善社区健康提供了一种不同的方式。
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