Hughes Julie M, Taylor Kathryn M, Guerriere Katelyn I, Smith Nathaniel I, Staab Jeffery S, Walker Leila A, Staab Janet E, Bartlett Paul M, Spiering Barry A, Nguyen Vy T, Proctor Susan P, Foulis Stephen A, Bouxsein Mary L, Popp Kristin L
Military Performance Division United States Army Research Institute of Environmental Medicine Natick MA USA.
Research Service VA Boston Healthcare System Boston MA USA.
JBMR Plus. 2023 Mar 2;7(4):e10719. doi: 10.1002/jbm4.10719. eCollection 2023 Apr.
Basic combat training (BCT) is a physically rigorous period at the beginning of a soldier's career that induces bone formation in the tibia. Race and sex are determinants of bone properties in young adults but their influences on changes in bone microarchitecture during BCT are unknown. The purpose of this work was to determine the influence of sex and race on changes in bone microarchitecture during BCT. Bone microarchitecture was assessed at the distal tibia via high-resolution peripheral quantitative computed tomography at the beginning and end of 8 weeks of BCT in a multiracial cohort of trainees (552 female, 1053 male; mean ± standard deviation [SD] age = 20.7 ± 3.7 years) of which 25.4% self-identified as black, 19.5% as race other than black or white (other races combined), and 55.1% as white. We used linear regression models to determine whether changes in bone microarchitecture due to BCT differed by race or sex, after adjusting for age, height, weight, physical activity, and tobacco use. We found that trabecular bone density (Tb.BMD), thickness (Tb.Th), and volume (Tb.BV/TV), as well as cortical BMD (Ct.BMD) and thickness (Ct.Th) increased following BCT in both sexes and across racial groups (+0.32% to +1.87%, all < 0.01). Compared to males, females had greater increases in Tb.BMD (+1.87% versus +1.40%; = 0.01) and Tb.Th (+0.87% versus +0.58%; = 0.02), but smaller increases in Ct.BMD (+0.35% versus +0.61%; < 0.01). Compared to black trainees, white trainees had greater increases in Tb.Th (+0.82% versus +0.61%; = 0.03). Other races combined and white trainees had greater increases in Ct.BMD than black trainees (+0.56% and + 0.55% versus +0.32%; both ≤ 0.01). Changes in distal tibial microarchitecture, consistent with adaptive bone formation, occur in trainees of all races and sexes, with modest differences by sex and race. Published 2023. This article is a U.S. Government work and is in the public domain in the USA. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
基础战斗训练（BCT）是士兵职业生涯开始时一段身体要求严格的时期，会促使胫骨骨质生成。种族和性别是年轻成年人骨特性的决定因素，但它们对BCT期间骨微结构变化的影响尚不清楚。这项研究的目的是确定性别和种族对BCT期间骨微结构变化的影响。在一个多种族学员队列（552名女性，1053名男性；平均±标准差[SD]年龄 = 20.7±3.7岁）的BCT 8周开始和结束时，通过高分辨率外周定量计算机断层扫描评估胫骨远端的骨微结构，其中25.4%自我认定为黑人，19.5%为非黑或白的其他种族（其他种族合并），55.1%为白人。在调整年龄、身高、体重、身体活动和烟草使用情况后，我们使用线性回归模型来确定BCT导致的骨微结构变化在种族或性别上是否存在差异。我们发现，在所有性别和种族组中，BCT后小梁骨密度（Tb.BMD）、厚度（Tb.Th）和体积（Tb.BV/TV）以及皮质骨密度（Ct.BMD）和厚度（Ct.Th）均增加（+0.32%至 +1.87%，均<0.01）。与男性相比，女性的Tb.BMD增加幅度更大（+1.87%对 +1.40%；P = 0.01）和Tb.Th增加幅度更大（+0.87%对 +0.58%；P = 0.02），但Ct.BMD增加幅度较小（+0.35%对 +0.61%；P<0.01）。与黑人学员相比，白人学员的Tb.Th增加幅度更大（+0.82%对 +0.61%；P = 0.03）。其他种族合并组和白人学员的Ct.BMD增加幅度大于黑人学员（+0.56%和 +0.55%对 +0.32%；均≤0.01）。胫骨远端微结构的变化与适应性骨质生成一致，发生在所有种族和性别的学员中，性别和种族之间存在适度差异。2023年发表。本文为美国政府作品，在美国属于公共领域。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
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