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病例报告：与莫德纳mRNA新冠疫苗接种相关的精神症状及其缓解情况

Case Report: Psychiatric Symptoms Associated With the Moderna mRNA COVID-19 Vaccine Administration and Their Resolution.

作者信息

Helman Daniel S

机构信息

Education Division, College of Micronesia-FSM, Yap Campus, Yap, Federated States of Micronesia.

出版信息

Clin Med Insights Case Rep. 2023 Apr 12;16:11795476231166626. doi: 10.1177/11795476231166626. eCollection 2023.

DOI:10.1177/11795476231166626
PMID:37065637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10099908/
Abstract

This case report describes the sudden presentation and successful cessation of psychiatric symptoms following the first administration of the Moderna mRNA vaccine against the SARS-CoV-2 virus during early 2021. The process of discovery of symptoms is described, along with an empirical procedure which identified St. John's wort as the mediating agent. Implications for self-medication of mild depression are discussed. Hypericin, a constituent agent in St. John's wort, interacts with the SARS-CoV-2 spike protein. Sensitization to hypericin following vaccine administration is consistent with the observed symptoms.

摘要

本病例报告描述了2021年初首例接种针对SARS-CoV-2病毒的Moderna mRNA疫苗后精神症状的突然出现及成功消除。文中描述了症状的发现过程，以及确定圣约翰草为介导因素的经验性程序。还讨论了对轻度抑郁症自我用药的影响。圣约翰草中的成分金丝桃素与SARS-CoV-2刺突蛋白相互作用。接种疫苗后对金丝桃素的致敏反应与观察到的症状相符。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/10102954/e211083d3bdf/10.1177_11795476231166626-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/10102954/d8243bdcc677/10.1177_11795476231166626-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/10102954/e211083d3bdf/10.1177_11795476231166626-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/10102954/d8243bdcc677/10.1177_11795476231166626-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b02/10102954/e211083d3bdf/10.1177_11795476231166626-fig2.jpg

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Case Report: Psychiatric Symptoms Associated With the Moderna mRNA COVID-19 Vaccine Administration and Their Resolution.病例报告：与莫德纳mRNA新冠疫苗接种相关的精神症状及其缓解情况
Clin Med Insights Case Rep. 2023 Apr 12;16:11795476231166626. doi: 10.1177/11795476231166626. eCollection 2023.
2
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本文引用的文献

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A review of adverse effects of COVID-19 vaccines.新型冠状病毒肺炎疫苗不良反应综述
Infez Med. 2022 Mar 1;30(1):1-10. doi: 10.53854/liim-3001-1. eCollection 2022.
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Managing a patient with bipolar disorder associated with COVID-19: A case report from Qatar.管理一名患有与COVID-19相关的双相情感障碍的患者：卡塔尔的一例病例报告。
Clin Case Rep. 2021 Mar 11;9(4):2285-2288. doi: 10.1002/ccr3.4015. eCollection 2021 Apr.
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Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay.
小分子与 SARS-CoV-2 木瓜蛋白酶样蛋白酶的相互作用：使用酶抑制测定法进行的体外验证和体外验证蛋白酶活性抑制的计算研究。
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St John's wort (Hypericum perforatum)-induced psychosis: a case report.圣约翰草（贯叶连翘）所致精神病：一例报告。
J Med Case Rep. 2017 May 15;11(1):137. doi: 10.1186/s13256-017-1302-7.
6
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.贯叶连翘（圣约翰草）在抑郁症中的临床应用：一项荟萃分析。
J Affect Disord. 2017 Mar 1;210:211-221. doi: 10.1016/j.jad.2016.12.048. Epub 2017 Jan 3.
7
Hypericin--the facts about a controversial agent.金丝桃素——关于一种有争议物质的事实
Curr Pharm Des. 2005;11(2):233-53. doi: 10.2174/1381612053382287.
8
Self-determination in clinical practice: the psychiatric patient's point of view.临床实践中的自主决定权：精神病患者的视角。
Nurs Ethics. 1996 Dec;3(4):329-44. doi: 10.1177/096973309600300406.
9
Antiretroviral activities of hypericin and rose bengal: photodynamic effects on Friend leukemia virus infection of mice.金丝桃素与孟加拉玫瑰红的抗逆转录病毒活性：对小鼠Friend白血病病毒感染的光动力效应
Antiviral Res. 1993 Jun;21(2):119-27. doi: 10.1016/0166-3542(93)90048-n.
10
Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation.使用金丝桃素和孟加拉玫瑰红对人类免疫缺陷病毒及其他包膜病毒的感染性进行光动力灭活：抑制融合和多核巨细胞形成。
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62. doi: 10.1073/pnas.90.1.158.