Gonzales-Moreno Candelaria, Fernandez-Hubeid Lucia E, Holgado Andrea, Virgolini Miriam B
Departamento de Farmacología Otto Orsingher. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba, Córdoba, Argentina.
IFEC-CONICET. Departamento de Farmacología Otto Orsingher. Facultad de Ciencias Químicas. Universidad Nacional de Córdoba, Córdoba, Argentina.
MicroPubl Biol. 2023 Mar 23;2023. doi: 10.17912/micropub.biology.000815. eCollection 2023.
Exposure to the herbicide paraquat (PQ; 1,1'-dimethyl-4,4'-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, 10 mM, 50 mM, or 100 mM) dose-dependently increased mortality in after exposure (immediate toxicity), while this effect was more evident 24 hours thereafter (delayed toxicity). Importantly, pretreatment with NAC 0.5 mM for one hour partially prevented mortality in the immediate assay, while it had no effect in the delayed test, revealing the importance of long-term studies when evaluating toxicity.
接触除草剂百草枯（PQ；1,1'-二甲基-4,4'-联吡啶二氯化物）会影响细胞的氧化还原平衡，这种影响可通过抗氧化剂（包括N-乙酰半胱氨酸（NAC））来恢复。接触PQ（0 mM、10 mM、50 mM或100 mM）一小时后，死亡率呈剂量依赖性增加（即时毒性），而这种影响在24小时后更为明显（延迟毒性）。重要的是，在即时试验中，用0.5 mM的NAC预处理一小时可部分预防死亡，而在延迟试验中则无效，这揭示了评估毒性时进行长期研究的重要性。
