溴隐亭治疗帕金森症
Bromocriptine in the treatment of parkinsonism.
作者信息
Parkes J D
出版信息
Drugs. 1979 May;17(5):365-82. doi: 10.2165/00003495-197917050-00006.
Abstract
Bromocriptine alters the motor behaviour of animals and improves the motor defect of parkinsonism. Changes in movement are accompanied by biochemical changes in the central nervous system, consistent with the idea that bromocriptine has a dopamine agonist action in the basal ganglia and also in the mesolimbic system and hypothalamus. The overall anti-parkinsonian effect of bromocriptine is similar to that of l-dopa alone or with benserazide (a decarboxylase inhibitor) when optimum doses are used, although individual patients may respond better to 1 drug than to the other.
摘要
溴隐亭可改变动物的运动行为，并改善帕金森病的运动缺陷。运动变化伴随着中枢神经系统的生化变化，这与溴隐亭在基底神经节、中脑边缘系统和下丘脑具有多巴胺激动剂作用的观点一致。当使用最佳剂量时，溴隐亭的总体抗帕金森病效果与单独使用左旋多巴或与苄丝肼（一种脱羧酶抑制剂）联合使用时相似，尽管个别患者对一种药物的反应可能比对另一种药物更好。
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Bromocriptine in the treatment of parkinsonism.溴隐亭治疗帕金森症
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