Ohman S, Björkander J, Dreborg S, Lanner A, Malling H J, Weeke B
Allergy. 1986 Feb;41(2):81-8. doi: 10.1111/j.1398-9995.1986.tb00282.x.
Monomethoxy polyethylene glycol (mPEG) modified honey bee venom (HBV) immunotherapy (IT) has been studied in 14 patients allergic to honey bee venom. Doses could be increased more rapidly and higher doses were reached compared to regular venom immunotherapy. No general side effects were seen, although large local swellings were found somewhat more often than with regular HBV. Most patients could easily be switched from the modified to the unmodified venom. Eight patients experienced and tolerated field stings. Skin testing showed a decreased allergenicity of the mPEG-HBV. The mean HBV-specific IgE level was below pre-treatment level already after only 6 weeks of IT. The HBV-specific IgG response was very good.
单甲氧基聚乙二醇（mPEG）修饰的蜂毒免疫疗法（IT）已在14名对蜂毒过敏的患者中进行了研究。与常规毒液免疫疗法相比，剂量增加得更快，且达到了更高的剂量。虽然发现局部大肿胀比常规蜂毒免疫疗法更常见，但未观察到一般副作用。大多数患者可以很容易地从修饰毒液转换为未修饰毒液。8名患者经历并耐受了野外蜇刺。皮肤试验显示mPEG-蜂毒的致敏性降低。仅在免疫疗法6周后，平均蜂毒特异性IgE水平就已低于治疗前水平。蜂毒特异性IgG反应非常好。
