Müller U, Lanner A, Schmid P, Bischof M, Dreborg S, Hoigné R
Int Arch Allergy Appl Immunol. 1985;77(1-2):201-3. doi: 10.1159/000233786.
24 patients with honey bee sting allergy were treated with either honey bee venom (HBV) or monomethoxy polyethylene glycol-coupled HBV (PEG-HBV) in a double blind trial. Both treatments induced a strong increase in HBV-specific IgG antibodies in most patients. Immunotherapy with PEG-HBV was much better tolerated than that with HBV. Conversely, patients on HBV did considerably better during a sting challenge with a living honey bee. Only 4 developed a large local and one a mild systemic reaction compared to 7 large local and 3 moderate to severe systemic reactions in the PEG-HBV-group. A higher maintenance dose of PEG-HBV may still be well tolerated but prove more effective at reexposure.
在一项双盲试验中，24名对蜜蜂叮咬过敏的患者接受了蜜蜂毒液（HBV）或单甲氧基聚乙二醇偶联的HBV（PEG-HBV）治疗。两种治疗方法均使大多数患者体内HBV特异性IgG抗体大幅增加。PEG-HBV免疫疗法的耐受性远优于HBV免疫疗法。相反，接受HBV治疗的患者在被活蜜蜂叮咬激发试验期间表现得更好。与PEG-HBV组中7例出现大面积局部反应和3例出现中度至重度全身反应相比，接受HBV治疗的患者中只有4例出现大面积局部反应，1例出现轻度全身反应。更高剂量的PEG-HBV维持治疗可能仍具有良好的耐受性，但在再次接触时可能会更有效。
