Department of Neurology.
Department of Biomedical Engineering, Konkuk University, Chungju, Korea.
Technol Health Care. 2023;31(S1):515-523. doi: 10.3233/THC-236045.
A representative symptom of Parkinson's disease (PD) is resting tremor. The clinical manifestation of scans without evidence of dopaminergic deficit (SWEDD) is similar to it of PD, though the phenomenology of SWEDD is not well known.
In the present study, the resting tremor of 9 SWEDD patients was quantitatively compared with that of 11 PD patients.
Four 3-axis gyro sensors were attached on the index finger, thumb, dorsum of the hand, and arm of the more tremulous side. Root mean square (RMS) angular speed and angular displacement as well as irregularity of angular speed and displacement were derived from the sensor data.
Although disease duration and Hoehn and Yahr stages were comparable, SWEDD patients exhibited different tremor features from PD patients. Significantly faster RMS angular speed and greater RMS angular displacement (p< 0.05) were observed in PD patients than in SWEDD patients. The irregularity of angular displacement of pitch direction at the dorsum of the hand was greater in SWEDD patients than in PD patients (p< 0.05).
These results indicate that quantitative indices obtained from resting tremor task could be important biomarkers for identifying potential patients with SWEDD among patients diagnosed with PD.
帕金森病（PD）的一个代表性症状是静止性震颤。扫描未见多巴胺能缺陷（SWEDD）的临床表现类似于 PD，但 SWEDD 的现象学尚不清楚。
本研究对 9 例 SWEDD 患者和 11 例 PD 患者的静止性震颤进行了定量比较。
将四个三轴陀螺仪传感器分别贴在震颤较严重侧的食指、拇指、手背和手臂上。从传感器数据中得出均方根（RMS）角速度和角位移以及角速度和位移的不规则性。
尽管疾病持续时间和 Hoehn 和 Yahr 分期相似，但 SWEDD 患者与 PD 患者的震颤特征不同。与 SWEDD 患者相比，PD 患者的 RMS 角速度更快，RMS 角位移更大（p<0.05）。与 PD 患者相比，SWEDD 患者的手背俯仰方向角位移不规则性更大（p<0.05）。
这些结果表明，从静止性震颤任务中获得的定量指标可能是在 PD 患者中识别潜在 SWEDD 患者的重要生物标志物。
