Department of Neurology, Korea University College of Medicine, Ansan Hospital, Ansan, Korea.
School of Biomedical Engineering, Konkuk University, Chungju, Korea.
Technol Health Care. 2020;28(S1):499-507. doi: 10.3233/THC-209050.
It is important to quantitatively assess tremor for accurate diagnosis and evaluation of the response to interventions in patients with essential tremor (ET).
The purpose of this study was to investigate the relationship between quantitative measures of postural tremor and clinical rating scale in patients with ET.
18 ET patients performed a postural tremor task that required them to hold their arms outstretched parallel to the floor while wearing a gyro sensor based measurement system. The time domain variables were derived from the sensor signals. Additionally, the frequency domain variables were derived from the power spectrum of the angular velocity signal. Spearman correlation analysis was employed in the relationship between the variables and clinical score.
The RMS angular velocity of roll and yaw directions at the hand joint were strongly correlated with the clinical rating scale (r= 0.7, p< 0.01). Similarly, the peak power of roll and yaw directions at the hand joint were moderately correlated with the clinical rating scale (r= 0.61 and r= 0.67, p< 0.01). In contrast, no significant correlation coefficients were observed in the peak frequency (p> 0.05).
These results indicate that hand tremor of roll and yaw directions are more associated with assessment of severity of ET compared to other joints. This study suggests that quantitative measurements of postural tremor should be considered as tremor directionality as well as attachment location.
对于特发性震颤（ET）患者的准确诊断和干预效果评估，定量评估震颤非常重要。
本研究旨在探讨 ET 患者姿势性震颤的定量测量与临床评分量表之间的关系。
18 名 ET 患者进行了姿势性震颤任务，要求他们在佩戴基于陀螺仪传感器的测量系统的情况下将手臂伸展平行于地面。从传感器信号中得出时域变量，从角速度信号的功率谱中得出频域变量。采用 Spearman 相关分析对变量与临床评分之间的关系进行分析。
手部关节的横滚和俯仰方向的 RMS 角速度与临床评分量表高度相关（r=0.7，p<0.01）。同样，手部关节的横滚和俯仰方向的峰值功率与临床评分量表中度相关（r=0.61 和 r=0.67，p<0.01）。相比之下，峰值频率无显著相关系数（p>0.05）。
这些结果表明，与其他关节相比，横滚和俯仰方向的手部震颤与 ET 严重程度的评估更为相关。本研究表明，应将姿势性震颤的定量测量视为震颤的方向性以及附着位置。
