Business Economics Research Institute, Harbin University of Commerce, Harbin, Heilongjiang, China.
Department of Rehabilitation Therapy, Wuyi University, Nanping, Fujian, China.
Technol Health Care. 2023;31(S1):565-575. doi: 10.3233/THC-236050.
Heilongjiang Province is a frontier province with distinctive characteristics, fertile land and rich products.
This study provides a new method for qualitatively studying flavonoids in traditional Chinese medicine and a new auxiliary means for identifying flavonoid isomers.
The flavonoids in Polygala fallax Hemsl were identified by ultra-performance liquid chromatography-photo-diode array (PDA)-quadrupole-electro- static field orbitrap mass spectrometry tandem by UV Spectrum, primary and secondary high-resolution mass spectrometry (MS1/MS2) cleavage of fragments combined with databases, mass spectrometry cleavage patterns and literature.
The established QSRR model was used to verify the flavonoids identified from the Polygala fallax Hemsl.
The structure of multiple Polygala fallax Hemsl has been identified using various spectral methods. The tumor cytotoxic activity of the isolated compounds was evaluated. This paper is of great significance for further elucidating the pharmacodynamic substance basis and further developing and utilizing Polygala fallax Hemsl.
黑龙江省是一个具有鲜明特色的边疆省份，土地肥沃，物产丰富。
本研究为中药中黄酮类化合物的定性研究提供了一种新方法，为黄酮类异构体的鉴定提供了一种新的辅助手段。
采用超高效液相色谱-光电二极管阵列（PDA）-四极杆-静电场轨道阱质谱联用技术，结合紫外光谱、一级和二级高分辨质谱（MS1/MS2）碎片裂解、数据库、质谱裂解图谱和文献，对黄花倒水莲中的黄酮类化合物进行鉴定。
利用建立的 QSRR 模型对黄花倒水莲中鉴定的黄酮类化合物进行了验证。
采用多种光谱方法对黄花倒水莲的结构进行了鉴定。对分离得到的化合物进行了肿瘤细胞毒性活性评价。本研究对于进一步阐明黄花倒水莲的药效物质基础，进一步开发和利用黄花倒水莲具有重要意义。
