Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
School of Life Sciences, Southwest Jiaotong University, Chengdu 610031, China.
Fitoterapia. 2022 Sep;161:105256. doi: 10.1016/j.fitote.2022.105256. Epub 2022 Jul 21.
Six new sugar esters (1-6), named tenuifolisides F-G (1-2) and tenuifolioses W-Z (3-6), together with 16 known compounds (7-22) were isolated from the roots of Polygala tenuifolia. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS techniques together with chemical methods. All the compounds were evaluated for the cytoprotective activity against hydrogen peroxide (HO)-induced oxidative stress in human keratinocyte HaCaT cells. Compounds 4, 5, 13, 20 and 22 showed strong cytoprotective effect.
从远志根中分离得到了 6 个新的糖酯（1-6），分别命名为远志糖苷 F-G（1-2）和远志糖苷 W-Z（3-6），以及 16 个已知化合物（7-22）。通过 1D、2D NMR 和 HRESIMS 技术以及化学方法阐明了新化合物的化学结构。所有化合物均评估了对人角质形成细胞 HaCaT 细胞中过氧化氢（HO）诱导的氧化应激的细胞保护活性。化合物 4、5、13、20 和 22 表现出很强的细胞保护作用。
