Department of Anatomy and Neurosciences, Amsterdam UMC location Vrije Universiteit Amsterdam, de Boelelaan 1108, Amsterdam, the Netherlands.
Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands.
Brain Imaging Behav. 2023 Aug;17(4):425-435. doi: 10.1007/s11682-023-00770-w. Epub 2023 Apr 17.
Many patients with glioma, primary brain tumors, suffer from poorly understood executive functioning deficits before and/or after tumor resection. We aimed to test whether frontoparietal network centrality of multilayer networks, allowing for integration across multiple frequencies, relates to and predicts executive functioning in glioma. Patients with glioma (n = 37) underwent resting-state magnetoencephalography and neuropsychological tests assessing word fluency, inhibition, and set shifting before (T1) and one year after tumor resection (T2). We constructed binary multilayer networks comprising six layers, with each layer representing frequency-specific functional connectivity between source-localized time series of 78 cortical regions. Average frontoparietal network multilayer eigenvector centrality, a measure for network integration, was calculated at both time points. Regression analyses were used to investigate associations with executive functioning. At T1, lower multilayer integration (p = 0.017) and epilepsy (p = 0.006) associated with poorer set shifting (adj. R = 0.269). Decreasing multilayer integration (p = 0.022) and not undergoing chemotherapy at T2 (p = 0.004) related to deteriorating set shifting over time (adj. R = 0.283). No significant associations were found for word fluency or inhibition, nor did T1 multilayer integration predict changes in executive functioning. As expected, our results establish multilayer integration of the frontoparietal network as a cross-sectional and longitudinal correlate of executive functioning in glioma patients. However, multilayer integration did not predict postoperative changes in executive functioning, which together with the fact that this correlate is also found in health and other diseases, limits its specific clinical relevance in glioma.
许多患有神经胶质瘤（原发性脑肿瘤）的患者在肿瘤切除前后存在执行功能障碍，但这些障碍的原因尚未被充分理解。我们旨在测试多层网络的额顶网络中心性（允许跨多个频率进行整合）是否与神经胶质瘤患者的执行功能相关，并预测其执行功能。37 名神经胶质瘤患者在肿瘤切除前（T1）和一年后（T2）接受静息态脑磁图和神经心理学测试，以评估词汇流畅性、抑制和定势转移。我们构建了包含六个层的二进制多层网络，每个层代表 78 个皮质区域源定位时间序列之间的特定频率功能连接。在两个时间点计算平均额顶网络多层特征向量中心性，作为网络整合的度量。回归分析用于研究与执行功能的关联。在 T1 时，较低的多层整合（p=0.017）和癫痫（p=0.006）与较差的定势转移相关（adj. R=0.269）。T2 时的多层整合下降（p=0.022）和未进行化疗（p=0.004）与随时间推移定势转移的恶化相关（adj. R=0.283）。在词汇流畅性或抑制方面未发现显著关联，T1 多层整合也不能预测执行功能的变化。正如预期的那样，我们的结果确定了额顶网络的多层整合是神经胶质瘤患者执行功能的一个横断和纵向相关因素。然而，多层整合并不能预测术后执行功能的变化，考虑到这种相关性也存在于健康和其他疾病中，这限制了它在神经胶质瘤中的具体临床相关性。
