Tanzilli Antonio, Pace Andrea, Prosperini Luca, Oppido Piero Andrea, Telera Stefano, Rasile Fabrizio, Farneti Alessia, Marucci Laura, Villani Veronica
Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, 00144, Italy.
Department of Neurosciences, S. Camillo-Forlanini Hospital, C.ne Gianicolense 87, Rome, 00152, Italy.
Future Oncol. 2022 May;18(15):1839-1848. doi: 10.2217/fon-2021-0963. Epub 2022 Feb 24.
We performed longitudinal evaluations of the neurocognitive status in glioma patients to describe possible variations over the course of illness. Glioma patients underwent a complete battery of standardized neuropsychological tests pre-radiotherapy at 6, 12 and 24 months. We enrolled 130 patients, 67.7% of whom had a deficit in at least one cognitive domain. The most affected domains included executive function (n = 68, 52.3%), long-term memory (n = 46, 35.3%) and short-term memory (n = 39, 30%). At follow-up, cognitive status worsened in 31.5%, remained unchanged in 38.4% and improved in 30.1% of patients. This is one of few studies investigating longitudinal neurocognitive status in a wide sample of patients to monitor neuropsychological changes due to tumor progression and treatment administration.
我们对胶质瘤患者的神经认知状态进行了纵向评估，以描述疾病过程中可能出现的变化。胶质瘤患者在放疗前、放疗后6个月、12个月和24个月接受了一整套标准化神经心理学测试。我们招募了130名患者，其中67.7%的患者至少在一个认知领域存在缺陷。受影响最严重的领域包括执行功能（n = 68，52.3%）、长期记忆（n = 46，35.3%）和短期记忆（n = 39，30%）。在随访中，31.5%的患者认知状态恶化，38.4%的患者保持不变，30.1%的患者有所改善。这是少数几项在大量患者样本中研究纵向神经认知状态，以监测肿瘤进展和治疗导致的神经心理学变化的研究之一。
