全氟烷基物质（PFAS）暴露与老年人非酒精性脂肪性肝病风险：来自 NHANES 2003-2014 的结果。
Perfluoroalkyl substance (PFAS) exposure and risk of nonalcoholic fatty liver disease in the elderly: results from NHANES 2003-2014.
机构信息
Department of Hepatobiliary Surgery, Jiujiang No. 1 People's Hospital, Jiujiang, 332000, Jiangxi Province, China.
Department of Endocrinology, Jiujiang No. 1 People's Hospital, Jiujiang , Jiangxi Province, China.
出版信息
Environ Sci Pollut Res Int. 2023 May;30(23):64342-64351. doi: 10.1007/s11356-023-26941-2. Epub 2023 Apr 17.
This study aimed to investigate the association between perfluoroalkyl substance (PFAS) exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in the elderly. Our sample included 1420 participants (≥ 60 years) from the 2003-2014 NHANES study with available serum PFASs, covariates, and outcomes. NAFLD was defined based on the hepatic steatosis index. Weighted binary logistic regression was utilized to calculate the odds ratio (OR) and 95% confidence intervals for each chemical. Results suggested that increase in PFOA concentrations was positively associated with risk of NAFLD in adjusted models. PFNA was also significantly associated with NAFLD development in adjusted linear regression. The effect of PFOA or PFNA on NAFLD development was found to be linear in the trend test. This study added novel evidence that exposure to PFASs (PFOA and PFNA) might be associated with NAFLD development.
本研究旨在探讨老年人中全氟烷基物质（PFAS）暴露与非酒精性脂肪性肝病（NAFLD）风险之间的关联。我们的样本包括来自 2003-2014 年 NHANES 研究的 1420 名（≥60 岁）参与者，这些参与者具有可用的血清 PFASs、协变量和结局。NAFLD 根据肝脂肪变性指数定义。采用加权二项逻辑回归计算每种化学物质的比值比（OR）和 95%置信区间。结果表明，在调整后的模型中，PFOA 浓度的增加与 NAFLD 风险呈正相关。PFNA 在调整后的线性回归中也与 NAFLD 的发生显著相关。趋势检验表明，PFOA 或 PFNA 对 NAFLD 发生的影响呈线性。本研究提供了新的证据，表明 PFAS（PFOA 和 PFNA）暴露可能与 NAFLD 的发生有关。
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