单种及多种全氟烷基物质暴露与青少年叶酸水平的相关性研究：NHANES2007-2010。
Associations of single and multiple perfluoroalkyl substances exposure with folate among adolescents in NHANES 2007-2010.
机构信息
National Management Office of Neonatal Screening Project for Congenital Heart Disease (CHD), Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
National Health Commission (NHC) Key Lab. of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, 200237, China.
出版信息
Chemosphere. 2022 Nov;307(Pt 3):135995. doi: 10.1016/j.chemosphere.2022.135995. Epub 2022 Aug 15.
BACKGROUND
The accumulation of perfluoroalkyl substances (PFAS) in human body has raised concerns about the potential health impacts on children and adolescents. However, no study has evaluated the associations of PFAS exposure with folate concentrations among adolescents.
METHODS
In the present study, we mainly used three statistical approaches, namely multiple linear regression, Bayesian Kernel Machine Regression (BKMR), and quantile-based g-computation (Q-gcomp) models, to evaluate associations of individual PFAS and their mixtures with serum and red blood cell (RBC) folate concentrations in a sample of 721 adolescents from the NHANES 2007-2010.
RESULTS
In multiple linear regression models, for per unit increase in ln-transformed perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) concentrations, RBC folate concentrations decreased by 72.4 (95% confidence interval (CI): -112.7, -32.2), 58.3 (95% CI: -115.0, -1.6), 60.7 (95% CI: -107.5, -13.8), and 76.5 (95% CI: -119.0, -33.9) nmol/L, respectively. A similar significant inverse association was also observed between ln-transformed PFDA and serum folate. BKMR models further confirmed inverse associations of serum PFOS and PFDA with RBC folate, and serum PFDA with serum folate. However, the inverse associations of PFOA and PFNA with RBC folate shown in multiple linear regression model were not observed or less evident in BKMR analyses. We observed interactions of PFOA with PFOS, PFNA, and PFDA on RBC folate in BKMR models, with the negative slopes for PFOS, PFNA, and PFDA increased when PFOA concentration increased from the 10th percentile to the 90th percentile. Both BKMR and Q-gcomp models suggested that the mixtures of five PFAS showed inverse overall associations with RBC folate concentration.
CONCLUSIONS
The present study revealed that adolescent exposure to PFAS might affect serum and RBC folate concentrations.
背景
全氟烷基物质 (PFAS) 在人体内的积累引起了人们对其对儿童和青少年潜在健康影响的关注。然而，目前还没有研究评估 PFAS 暴露与青少年叶酸浓度之间的关系。
方法
本研究主要采用多元线性回归、贝叶斯核机器回归 (BKMR) 和基于分位数的 g 计算 (Q-gcomp) 模型三种统计方法，评估了 721 名来自 NHANES 2007-2010 青少年样本中单个 PFAS 及其混合物与血清和红细胞 (RBC) 叶酸浓度的关系。
结果
在多元线性回归模型中，ln 转化的全氟辛烷磺酸 (PFOS)、全氟辛酸 (PFOA)、全氟壬酸 (PFNA) 和全氟癸酸 (PFDA) 浓度每增加一个单位，RBC 叶酸浓度分别降低 72.4(95%置信区间 (CI)：-112.7，-32.2)、58.3(95% CI：-115.0，-1.6)、60.7(95% CI：-107.5，-13.8)和 76.5(95% CI：-119.0，-33.9)nmol/L。ln 转化的 PFDA 与血清叶酸之间也存在类似的显著负相关关系。BKMR 模型进一步证实了血清 PFOS 和 PFDA 与 RBC 叶酸以及血清 PFDA 与血清叶酸之间的负相关关系。然而，在 BKMR 分析中，多元线性回归模型中观察到的 PFOA 和 PFNA 与 RBC 叶酸之间的负相关关系并不明显或不太明显。我们在 BKMR 模型中观察到了 PFOA 与 PFOS、PFNA 和 PFDA 之间的相互作用，当 PFOA 浓度从第 10 百分位数增加到第 90 百分位数时，PFOS、PFNA 和 PFDA 的负斜率增加。BKMR 和 Q-gcomp 模型均表明，五种 PFAS 的混合物与 RBC 叶酸浓度呈负相关。
结论
本研究表明，青少年接触 PFAS 可能会影响血清和 RBC 叶酸浓度。
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