Tyler H R
Neurology. 1979 Jan;29(1):77-81. doi: 10.1212/wnl.29.1.77.
In a double-blind study, we evaluated the intramuscular administration of modified neurotoxin in 48 patients who were treated for 6 months. There was no evidence to support claims that patients receive any benefit from the neurotoxin. A significant number of patients had minor functional improvement, often of a transient nature, but these manifestations were more common in the placebo-treated patients than in those receiving neurotoxin. These variations in the course of motor neuron disease have not been stressed in the previous literature.
在一项双盲研究中，我们评估了48例接受治疗6个月的患者肌肉注射改良神经毒素的情况。没有证据支持患者能从神经毒素中获得任何益处的说法。相当多的患者有轻微的功能改善，且通常是短暂性的，但这些表现在接受安慰剂治疗的患者中比接受神经毒素治疗的患者中更常见。运动神经元病病程中的这些变化在以往文献中未得到强调。
