Reid Paul F
ReceptoPharm Inc., Plantation, FL 33313, USA.
Crit Rev Immunol. 2007;27(4):291-302. doi: 10.1615/critrevimmunol.v27.i4.10.
The use of snake venom in the treatment of multiple sclerosis has been, at best, controversial. The anecdotal reports for snake venom's beneficial effects in this condition may be supportable now by recent scientific evidence. Cobratoxin, a neurotoxin obtained from the venom of the Thailand cobra, has demonstrated several pharmacological activities that strongly support its use in this application. By employing a chemical detoxification step, the neurotoxin can be rendered safe for administration to humans with minimal side effects. This modified neurotoxin has demonstrated neuromodulatory, antiviral, and analgesic activity, elements associated with the multiple sclerosis condition. Modified cobratoxin has demonstrated potent immunosuppressive activity in acute and chronic animal models of the disease. The drug is under investigation for use in adrenomyeloneuropathy and clinical trials in Multiple sclerosis are planned.
蛇毒用于治疗多发性硬化症，即便往好里说，也是颇具争议的。关于蛇毒在此病症中有益效果的轶事报道，如今或许能得到近期科学证据的支持。眼镜蛇毒素是一种从泰国眼镜蛇毒液中提取的神经毒素，已展现出多种药理活性，有力地支持了其在该应用中的使用。通过采用化学解毒步骤，这种神经毒素可变得对人体给药安全，且副作用极小。这种经过改良的神经毒素已展现出神经调节、抗病毒和止痛活性，这些都是与多发性硬化症相关的因素。改良后的眼镜蛇毒素在该疾病的急性和慢性动物模型中已展现出强大的免疫抑制活性。该药物正在接受用于肾上腺脊髓神经病的研究，并且计划开展多发性硬化症的临床试验。
