Sahebjami H
Am Rev Respir Dis. 1986 May;133(5):769-72.
Rats approximately 3 wk of age were given one half of their measured daily food consumption for 4 to 5 wk until they lost approximately 25% of their initial body weight (starved group) and were compared with an age-matched fed group 20 wk after the beginning of the study. Final body weight and nose-to-tail length were significantly lower in the starved group, whereas dry and wet weights of the lung were similar in both groups. The maximal and minimal lung volumes and specific lung compliance in air- and saline-filled lungs were similar in both groups, but in starved rats the volume-pressure curve was shifted significantly downward and to the right of that of the fed group at 70 and 60% maximal lung volume with air and at 90% maximal lung volume with saline. Total lung content of protein, DNA, RNA, hydroxyproline, and elastin were similar in fed and starved groups. It appears that moderate weight loss during the postnatal period leads to somatic growth retardation but to insignificant changes in the lungs of adult rats.
给大约3周龄的大鼠喂食其每日食量的一半，持续4至5周，直至体重减轻约25%（饥饿组），并在研究开始20周后与年龄匹配的喂食组进行比较。饥饿组的最终体重和鼻尾长度显著低于喂食组，而两组肺的干重和湿重相似。两组空气填充和盐水填充肺的最大和最小肺容量以及比肺顺应性相似，但在饥饿大鼠中，在70%和60%最大肺容量空气填充时以及90%最大肺容量盐水填充时，体积-压力曲线明显向下并向右偏移至喂食组曲线的右侧。喂食组和饥饿组肺中蛋白质、DNA、RNA、羟脯氨酸和弹性蛋白的总量相似。看来出生后适度体重减轻会导致身体生长迟缓，但对成年大鼠的肺影响不大。
