Natural Compounds Department, Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia.
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119234, Russia.
Biochemistry (Mosc). 2023 Jan;88(Suppl 1):S21-S38. doi: 10.1134/S000629792314002X.
The review describes the role of telomeres and telomerase in tumor progression, as well as various mechanisms of the activation of telomerase reverse transcriptase (TERT) expression in CNS tumors and other cancers. The main mechanism of TERT activation involves acquisition of somatic mutations by the TERT gene promoter (TERTp). The article presents information on the TERTp structure and transcription factors directly interacting with TERTp and regulating its transcription. The prospects of using the mutational status of TERTp as a prognostic marker of CNS malignancies and other tumors with a common profile of TERTp mutations are discussed.
该综述描述了端粒和端粒酶在肿瘤进展中的作用，以及 CNS 肿瘤和其他癌症中端粒酶逆转录酶（TERT）表达激活的各种机制。TERT 激活的主要机制涉及 TERT 基因启动子（TERTp）获得体细胞突变。本文介绍了 TERTp 结构和直接与 TERTp 相互作用并调节其转录的转录因子的信息。讨论了将 TERTp 突变状态用作 CNS 恶性肿瘤和其他具有 TERTp 突变共同特征的肿瘤的预后标志物的前景。
