Sawall Stefan
Röntgenbildgebung und CT (E025), Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland.
Medizinische Fakultät, Universität Heidelberg, Heidelberg, Deutschland.
Radiologie (Heidelb). 2023 Jul;63(7):507-512. doi: 10.1007/s00117-023-01135-6. Epub 2023 Apr 17.
The introduction of energy-selective photon-counting detectors into clinical practice represents the next milestone in computed tomography (CT). In addition to significantly higher resolution, these detectors allow the implicit acquisition of dual or multispectral data in a single measurement through the use of typically freely selectable thresholds. This capability reignited the interest in new contrast agents based on heavy elements, so-called high‑z elements, for clinical CT.
The present article aims to investigate the potential suitability of different chemical elements as contrast agents and to discuss possible clinical applications, for example, K‑edge imaging or simultaneous application of different contrast agents.
First preclinical experiments as well as experiments in large animals could demonstrate potential advantages of contrast agents based on heavy elements. For example, such contrast agents promise a significant increase in image contrast compared to conventional iodine-based agents.
将能量选择性光子计数探测器引入临床实践是计算机断层扫描（CT）的下一个里程碑。除了显著更高的分辨率外，这些探测器还允许通过使用通常可自由选择的阈值在单次测量中隐式获取双光谱或多光谱数据。这种能力重新点燃了人们对基于重元素（即所谓的高Z元素）的新型造影剂用于临床CT的兴趣。
本文旨在研究不同化学元素作为造影剂的潜在适用性，并讨论可能的临床应用，例如K边成像或不同造影剂的同时应用。
首次临床前实验以及大型动物实验能够证明基于重元素的造影剂的潜在优势。例如，与传统的碘基造影剂相比，此类造影剂有望显著提高图像对比度。
